DegronMD - Q92633(LPAR1)

FUNCTION: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S12L	TCGA-D3-A8GM	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1944
p.S12L	DO50288	SKCM	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1944
p.F16L	TCGA-DK-AA74	BLCA	TCGA	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.F16L	DO219011	BLCA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.S7F	TCGA-GN-A266	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7982
p.S7F	DO229453	SKCA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7982
p.S7F	DO37432	SKCM	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7982
p.I11V	DO8264	COAD	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2222
p.T17P	DO233227	GACA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0556
p.I11M	DO233951	GACA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2222
p.Q13K	DO229026	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1667
p.E14K	DO222434	MELA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1389
p.E14K	DO222632	MELA	ICGC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1389
p.E10K	SNU-81	large intestine	COSMIC	AISTS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LPAR1

UniProt ID: Q92633

Entrez ID: 1902

Protein name: Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LPAR1 in