DegronMD

Uniprot ID: Q92633

Source protein: Lysophosphatidic acid receptor 1

Source gene: LPAR1

Class: DEG_SPOP_SBC_1

Location: 3:7

E3 ligase: SPOP

DEGRON score: 0.8246

ASA_SCORE: 99.86

COIL: 0.9494

CONS_SCORE: 0.1946

DSS_SCORE: 0.5506

HELIX: 0.0294

FCONS_SCORE: 0.7552

RIG_SCORE: 0.769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S12L	TCGA-D3-A8GM	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	0.1944
p.S12L	DO50288	SKCM	ICGC	AISTS	DEG_SPOP_SBC_1	0.1944
p.F16L	TCGA-DK-AA74	BLCA	TCGA	AISTS	DEG_SPOP_SBC_1	0.0833
p.F16L	DO219011	BLCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.0833
p.S7F	TCGA-GN-A266	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	0.7982
p.S7F	DO229453	SKCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.7982
p.S7F	DO37432	SKCM	ICGC	AISTS	DEG_SPOP_SBC_1	0.7982
p.I11V	DO8264	COAD	ICGC	AISTS	DEG_SPOP_SBC_1	0.2222
p.T17P	DO233227	GACA	ICGC	AISTS	DEG_SPOP_SBC_1	0.0556
p.I11M	DO233951	GACA	ICGC	AISTS	DEG_SPOP_SBC_1	0.2222
p.Q13K	DO229026	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	0.1667
p.E14K	DO222434	MELA	ICGC	AISTS	DEG_SPOP_SBC_1	0.1389
p.E14K	DO222632	MELA	ICGC	AISTS	DEG_SPOP_SBC_1	0.1389
p.E10K	SNU-81	large_intestine	COSMIC	AISTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	149:153	AISTS	SPOP	0.6634	More...
P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	DEG_SPOP_SBC_1	14:18	AISTS	SPOP	0.8718	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	2047:2051	AISTS	SPOP	0.9931	More...
Q92633	Lysophosphatidic acid receptor 1	DEG_SPOP_SBC_1	3:7	AISTS	SPOP	0.8246	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	240:244	AISTS	SPOP	0.9994	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	583:587	AISTS	SPOP	0.8688	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1521:1525	AISTS	SPOP	0.7322	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	857:861	AISTS	SPOP	0.8563	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	61:65	AISTS	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons