DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_SPOP_SBC_1

Location: 2047:2051

E3 ligase: SPOP

DEGRON score: 0.9931

ASA_SCORE: 82.84

COIL: 0.938

CONS_SCORE: 0.2658

DSS_SCORE: 0.4248

HELIX: 0.0314

FCONS_SCORE: 0.8069

RIG_SCORE: 0.7373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2061W	TCGA-CR-7385	HNSC	TCGA	AISTS	DEG_SPOP_SBC_1	0.0556
p.G2061W	DO14282	HNSC	ICGC	AISTS	DEG_SPOP_SBC_1	0.0556
p.P2059H	DO228483	BRCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.1111
p.P2059H	DO229016	COCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.1111
p.V2044F	DO50865	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	0.25
p.S2049F	DO51494	PACA	ICGC	AISTS	DEG_SPOP_SBC_1	0.7982
p.G2040V	DO229242	THCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.1389
p.A2047T	SIDM02049	Pancreatic Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.7139
p.V2044I	SIDM00854	Burkitt's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.25
p.S2051L	SIDM00035	Thyroid Gland Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.7667
p.S2051L	ACH-000037	Sarcoma	CCLE	AISTS	DEG_SPOP_SBC_1	0.7667
p.A2046T	ACH-000994	Endometrial/Uterine Cancer	CCLE	AISTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	149:153	AISTS	SPOP	0.6634	More...
P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	DEG_SPOP_SBC_1	14:18	AISTS	SPOP	0.8718	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	2047:2051	AISTS	SPOP	0.9931	More...
Q92633	Lysophosphatidic acid receptor 1	DEG_SPOP_SBC_1	3:7	AISTS	SPOP	0.8246	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	240:244	AISTS	SPOP	0.9994	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	583:587	AISTS	SPOP	0.8688	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1521:1525	AISTS	SPOP	0.7322	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	857:861	AISTS	SPOP	0.8563	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	61:65	AISTS	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons