DegronMD

Uniprot ID: O95721

Source protein: Synaptosomal-associated protein 29

Source gene: SNAP29

Class: DEG_SPOP_SBC_1

Location: 149:153

E3 ligase: SPOP

DEGRON score: 0.6634

ASA_SCORE: 55.48

COIL: 0.4854

CONS_SCORE: 0.4583

DSS_SCORE: 0.6824

HELIX: 0.4806

FCONS_SCORE: 0.8891

RIG_SCORE: 0.6832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E148D	TCGA-AX-A1CE	UCEC	TCGA	AISTS	DEG_SPOP_SBC_1	0.3056
p.E148D	DO42280	UCEC	ICGC	AISTS	DEG_SPOP_SBC_1	0.3056
p.A158V	TCGA-EP-A2KB	LIHC	TCGA	AISTS	DEG_SPOP_SBC_1	0.1944
p.A158V	DO22932	LIHC	ICGC	AISTS	DEG_SPOP_SBC_1	0.1944
p.Q156H	TCGA-FS-A1ZP	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	0.25
p.Q156H	DO37703	SKCM	ICGC	AISTS	DEG_SPOP_SBC_1	0.25
p.S163G	DO228483	BRCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	DO229010	COCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	DO234285	ESAD	ICGC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00338	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00437	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00632	Non-Cancerous	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00264	Ewing's Sarcoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00466	Ovarian Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00530	Esophageal Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00482	Chronic Myelogenous Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00391	Plasma Cell Myeloma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00821	Kidney Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00294	Small Cell Lung Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00498	Colorectal Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00247	Gastric Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00612	Glioma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01653	Non-Cancerous	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00063	Melanoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00018	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00929	Chondrosarcoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00176	Chondrosarcoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00622	Glioblastoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01105	Melanoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00359	Colorectal Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01695	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01735	Biliary Tract Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00168	Head and Neck Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01526	Mesothelioma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00167	Head and Neck Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01770	Gastric Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01464	Pancreatic Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM00161	Biliary Tract Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.S163G	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.5
p.E157K	DO233951	GACA	ICGC	AISTS	DEG_SPOP_SBC_1	0.2222
p.S151I	DO229036	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	0.7341
p.I150V	DO23458	LINC	ICGC	AISTS	DEG_SPOP_SBC_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	149:153	AISTS	SPOP	0.6634	More...
P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	DEG_SPOP_SBC_1	14:18	AISTS	SPOP	0.8718	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	2047:2051	AISTS	SPOP	0.9931	More...
Q92633	Lysophosphatidic acid receptor 1	DEG_SPOP_SBC_1	3:7	AISTS	SPOP	0.8246	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	240:244	AISTS	SPOP	0.9994	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	583:587	AISTS	SPOP	0.8688	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1521:1525	AISTS	SPOP	0.7322	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	857:861	AISTS	SPOP	0.8563	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	61:65	AISTS	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AISTS

Degron related mutations and impact score

Drug responses associated with SNAP29 mutations

All proteins holding degron of AISTS