DegronMD

Uniprot ID: P13073

Source protein: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Source gene: COX4I1

Class: DEG_SPOP_SBC_1

Location: 14:18

E3 ligase: SPOP

DEGRON score: 0.8718

ASA_SCORE: 56.12

COIL: 0.4588

CONS_SCORE: 0.475

DSS_SCORE: 0.0932

HELIX: 0.2718

FCONS_SCORE: 1.2931

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S18C	TCGA-JW-A5VL	CESC	TCGA	AISTS	DEG_SPOP_SBC_1	0.7541
p.S18C	DO49976	CESC	ICGC	AISTS	DEG_SPOP_SBC_1	0.7541
p.V10F	DO229028	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	0.2222
p.R13Q	DO232761	PBCA	ICGC	AISTS	DEG_SPOP_SBC_1	0.3056
p.S26G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	149:153	AISTS	SPOP	0.6634	More...
P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	DEG_SPOP_SBC_1	14:18	AISTS	SPOP	0.8718	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	2047:2051	AISTS	SPOP	0.9931	More...
Q92633	Lysophosphatidic acid receptor 1	DEG_SPOP_SBC_1	3:7	AISTS	SPOP	0.8246	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	240:244	AISTS	SPOP	0.9994	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	583:587	AISTS	SPOP	0.8688	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1521:1525	AISTS	SPOP	0.7322	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	857:861	AISTS	SPOP	0.8563	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	61:65	AISTS	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons