DegronMD - Q9H694(BICC1)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L743V	TCGA-2H-A9GR	ESCA	TCGA	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P501L	TCGA-64-5781	LUAD	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.A508V	TCGA-AA-3660	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.3056
p.A508V	TCGA-AP-A056	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.3056
p.A499V	TCGA-AA-3663	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2222
p.I584M	TCGA-BA-6871	HNSC	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.6507
p.E750A	TCGA-CG-5720	STAD	TCGA	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.P500L	TCGA-CN-4740	HNSC	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.L517I	TCGA-CV-A45Z	HNSC	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.S587L	TCGA-CV-A6K2	HNSC	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.7667
p.I514T	TCGA-D1-A15X	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.T749M	TCGA-D1-A15X	UCEC	TCGA	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.2778
p.T749M	TCGA-VS-A9UD	CESC	TCGA	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.2778
p.H573Q	TCGA-D1-A3JQ	UCEC	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.0556
p.L589P	TCGA-EE-A3J5	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2778
p.A596V	TCGA-EY-A1GU	UCEC	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.0833
p.E591K	TCGA-FS-A1ZP	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2222
p.S576P	TCGA-QG-A5Z2	COAD	TCGA	AISTS	DEG_SPOP_SBC_1	583:587	Mutation blocking phosphorylation signal	0.5833
p.T495A	DO17522	KIRC	ICGC	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.T495A	DO229544	UTCA	ICGC	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.T495A	MM1S	haematopoietic and lymphoid tissue	COSMIC	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.D496Y	DO229028	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.C504F	DO229045	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7108
p.K503T	DO38183	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7306
p.G582R	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.3056
p.G582R	ACH-000892	Lung Cancer	CCLE	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.3056
p.G582R	NCI-H1563	lung	COSMIC	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.3056
p.T749K	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.2778
p.T749K	ACH-000408	Esophageal Cancer	CCLE	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.2778
p.T749K	TE-5	oesophagus	COSMIC	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.2778
p.V751D	SIDM00537	Colorectal Carcinoma	GDSC	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7785
p.V751D	ACH-000982	Colon/Colorectal Cancer	CCLE	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7785
p.V751D	ACH-001345	Colon/Colorectal Cancer	CCLE	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7785
p.V751D	GP5d	large intestine	COSMIC	VRTPTNT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7785
p.G590E	ACH-001028	Rhabdoid	CCLE	AISTS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BICC1

UniProt ID: Q9H694

Entrez ID: 80114

Protein name: Protein bicaudal C homolog 1 (Bic-C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BICC1 in