DegronMD

Uniprot ID: Q9H694

Source protein: Protein bicaudal C homolog 1

Source gene: BICC1

Class: DEG_SPOP_SBC_1

Location: 503:507

E3 ligase: SPOP

DEGRON score: 0.7982

ASA_SCORE: 51.9

COIL: 0.7988

CONS_SCORE: 0.3534

DSS_SCORE: 0.3448

HELIX: 0.1268

FCONS_SCORE: 0.895

RIG_SCORE: 0.6727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P501L	TCGA-64-5781	LUAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2778
p.A508V	TCGA-AA-3660	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.3056
p.A508V	TCGA-AP-A056	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.3056
p.A499V	TCGA-AA-3663	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2222
p.P500L	TCGA-CN-4740	HNSC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.25
p.L517I	TCGA-CV-A45Z	HNSC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.0556
p.I514T	TCGA-D1-A15X	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.T495A	DO17522	KIRC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.T495A	DO229544	UTCA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.T495A	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.D496Y	DO229028	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.C504F	DO229045	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7108
p.K503T	DO38183	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons