DegronMD - Q2VWP7(PRTG)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A408T	TCGA-55-8094	LUAD	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation altering degron motif	0.6028
p.A408T	DO24150	LUAD	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation altering degron motif	0.6028
p.A408T	ACH-001395	Breast Cancer	CCLE	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation altering degron motif	0.6028
p.R407K	TCGA-63-A5MS	LUSC	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation altering degron motif	0.7237
p.R407K	DO219161	LUSC	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation altering degron motif	0.7237
p.A397S	TCGA-AN-A0AJ	BRCA	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.0833
p.A397S	DO6040	BRCA	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.0833
p.R743G	TCGA-AN-A0AK	BRCA	TCGA	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.R743G	DO1608	BRCA	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.D1135N	TCGA-AX-A05Z	UCEC	TCGA	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.1944
p.D1135N	TCGA-BR-4256	STAD	TCGA	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.1944
p.D1135N	DO38743	STAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.1944
p.D1135N	DO40884	UCEC	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.1944
p.R1128W	TCGA-BR-8081	STAD	TCGA	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7523
p.R1128W	TCGA-MX-A5UJ	STAD	TCGA	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7523
p.R1128W	DO232761	PBCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7523
p.R1128W	DO48547	STAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7523
p.R1128W	DO38795	STAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7523
p.G1127V	TCGA-DX-AB2W	SARC	TCGA	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7532
p.G1127V	DO220095	SARC	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.7532
p.S415P	TCGA-EY-A1GD	UCEC	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.3056
p.S415P	DO42129	UCEC	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.3056
p.H1131N	TCGA-G2-A3IE	BLCA	TCGA	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.3056
p.H1131N	DO767	BLCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.3056
p.P725S	TCGA-H7-7774	HNSC	TCGA	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.P725S	DO14182	HNSC	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.I738M	TCGA-ND-A4W6	UCS	TCGA	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.I404V	TCGA-UF-A71D	HNSC	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.2778
p.I404V	DO52109	HNSC	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.2778
p.A730V	TCGA-VQ-A8P2	STAD	TCGA	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.A730V	DO51761	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.R743M	TCGA-VQ-A924	STAD	TCGA	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.R743M	DO51795	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.A397T	TCGA-W3-A828	SKCM	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.0833
p.A397T	DO51273	SKCM	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	406:414	Mutation rewiring degron network	0.0833
p.D1135H	DO218506	BRCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.1944
p.E1122K	DO50339	ESAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.25
p.S1133F	DO48218	ESCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.25
p.H726Y	DO233703	GACA	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1667
p.S1130T	DO228474	LICA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.6005
p.S1130T	DO228806	LICA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation altering degron motif	0.6005
p.N733K	DO228974	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.5806
p.A732D	DO229019	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7793
p.H1121N	DO229024	LICA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.2222
p.P725R	DO232861	NACA	ICGC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.S1120I	SIDM02050	Colorectal Carcinoma	GDSC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.1944
p.F739L	SIDM01106	Melanoma	GDSC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.25
p.F739L	SK-MEL-24	skin	COSMIC	ANTSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.25
p.A1115T	SIDM00217	Colorectal Carcinoma	GDSC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.0556
p.A1115T	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.0556
p.A1115T	SNU-1040	large intestine	COSMIC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.0556
p.S1140P	SIDM01770	Gastric Carcinoma	GDSC	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.0556
p.S1140P	ACH-000908	Gastric Cancer	CCLE	DSGRFS	DEG_SCF_TRCP1_1	1125:1130	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRTG

UniProt ID: Q2VWP7

Entrez ID: 283659

Protein name: Protogenin (Protein Shen-Dan)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRTG in