DegronMD

Uniprot ID: Q2VWP7

Source protein: Protogenin

Source gene: PRTG

Class: DEG_SCF_TRCP1_1

Location: 1125:1130

E3 ligase: BTRC

DEGRON score: 0.9904

ASA_SCORE: 80.5833

COIL: 0.8312

CONS_SCORE: 0.5758

DSS_SCORE: 0.7145

HELIX: 0.0898

FCONS_SCORE: 1.1666

RIG_SCORE: 0.5702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1135N	TCGA-AX-A05Z	UCEC	TCGA	DSGRFS	DEG_SCF_TRCP1_1	0.1944
p.D1135N	TCGA-BR-4256	STAD	TCGA	DSGRFS	DEG_SCF_TRCP1_1	0.1944
p.D1135N	DO38743	STAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.1944
p.D1135N	DO40884	UCEC	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.1944
p.R1128W	TCGA-BR-8081	STAD	TCGA	DSGRFS	DEG_SCF_TRCP1_1	0.7523
p.R1128W	TCGA-MX-A5UJ	STAD	TCGA	DSGRFS	DEG_SCF_TRCP1_1	0.7523
p.R1128W	DO232761	PBCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.7523
p.R1128W	DO48547	STAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.7523
p.R1128W	DO38795	STAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.7523
p.G1127V	TCGA-DX-AB2W	SARC	TCGA	DSGRFS	DEG_SCF_TRCP1_1	0.7532
p.G1127V	DO220095	SARC	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.7532
p.H1131N	TCGA-G2-A3IE	BLCA	TCGA	DSGRFS	DEG_SCF_TRCP1_1	0.3056
p.H1131N	DO767	BLCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.3056
p.D1135H	DO218506	BRCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.1944
p.E1122K	DO50339	ESAD	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.25
p.S1133F	DO48218	ESCA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.25
p.S1130T	DO228474	LICA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.6005
p.S1130T	DO228806	LICA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.6005
p.H1121N	DO229024	LICA	ICGC	DSGRFS	DEG_SCF_TRCP1_1	0.2222
p.S1120I	SIDM02050	Colorectal Carcinoma	GDSC	DSGRFS	DEG_SCF_TRCP1_1	0.1944
p.A1115T	SIDM00217	Colorectal Carcinoma	GDSC	DSGRFS	DEG_SCF_TRCP1_1	0.0556
p.A1115T	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGRFS	DEG_SCF_TRCP1_1	0.0556
p.A1115T	SNU-1040	large_intestine	COSMIC	DSGRFS	DEG_SCF_TRCP1_1	0.0556
p.S1140P	SIDM01770	Gastric Carcinoma	GDSC	DSGRFS	DEG_SCF_TRCP1_1	0.0556
p.S1140P	ACH-000908	Gastric Cancer	CCLE	DSGRFS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VWP7	Protogenin	DEG_SCF_TRCP1_1	1125:1130	DSGRFS	BTRC	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons