DegronMD

Uniprot ID: Q2VWP7

Source protein: Protogenin

Source gene: PRTG

Class: DEG_SPOP_SBC_1

Location: 732:736

E3 ligase: SPOP

DEGRON score: 0.8547

ASA_SCORE: 42.98

COIL: 0.704

CONS_SCORE: 0.5821

DSS_SCORE: 0.291

HELIX: 0.0092

FCONS_SCORE: 0.9373

RIG_SCORE: 0.7058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R743G	TCGA-AN-A0AK	BRCA	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.R743G	DO1608	BRCA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.P725S	TCGA-H7-7774	HNSC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.P725S	DO14182	HNSC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.I738M	TCGA-ND-A4W6	UCS	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2778
p.A730V	TCGA-VQ-A8P2	STAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2778
p.A730V	DO51761	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.2778
p.R743M	TCGA-VQ-A924	STAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.R743M	DO51795	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.H726Y	DO233703	GACA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1667
p.N733K	DO228974	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.5806
p.A732D	DO229019	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7793
p.P725R	DO232861	NACA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.F739L	SIDM01106	Melanoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.25
p.F739L	SK-MEL-24	skin	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons