DegronMD - P34910(EVI2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K140N	TCGA-06-6697	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.3056
p.K140Q	TCGA-06-6697	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.3056
p.Q119K	TCGA-49-AARQ	LUAD	TCGA	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2778
p.R132S	TCGA-69-7980	LUAD	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6316
p.S97F	TCGA-75-5126	LUAD	TCGA	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1111
p.T135I	TCGA-85-8276	LUSC	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7078
p.G323C	TCGA-AX-A2HC	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.S134C	TCGA-BB-4227	HNSC	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7541
p.P109T	TCGA-CJ-4923	KIRC	TCGA	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.Q80K	TCGA-D8-A1XL	BRCA	TCGA	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1944
p.D335Y	TCGA-DF-A2KV	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.D319N	TCGA-DG-A2KK	CESC	TCGA	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.0556
p.S88C	TCGA-DK-A6B6	BLCA	TCGA	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7541
p.E90Q	TCGA-SX-A71R	KIRP	TCGA	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.S103C	DO48576	BLCA	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.Q95K	DO1648	BRCA	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1667
p.D334N	DO51595	CESC	ICGC	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.G330A	DO12202	GBM	ICGC	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.754
p.P124T	DO18084	KIRC	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.P124T	DO18084	KIRC	ICGC	ARTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.E105Q	DO49777	KIRP	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1111
p.F77L	DO228986	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1111
p.Q84K	DO229029	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.P96T	DO229036	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.S112F	DO23711	LUAD	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.Q134K	DO51189	LUAD	ICGC	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6944
p.L117P	DO51414	PRAD	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7582
p.G83E	DO38855	STAD	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2778
p.G338C	DO41572	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1944
p.E322D	DO43755	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1389
p.P126A	DO229540	UTCA	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.P126A	DO229540	UTCA	ICGC	ARTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.K107E	SIDM00600	Thyroid Gland Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778
p.K107E	ACH-001528	Thyroid Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778
p.K107E	ACH-002055	Lymphoma	CCLE	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778
p.K107E	IHH-4	thyroid	COSMIC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778
p.V121M	SIDM00487	Colorectal Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.V121M	SIDM00487	Colorectal Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.V121M	ACH-000963	Colon/Colorectal Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.V121M	ACH-000963	Colon/Colorectal Cancer	CCLE	ARTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.V121M	CCK-81	large intestine	COSMIC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.V121M	CCK-81	large intestine	COSMIC	ARTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.A98T	SIDM00837	Colorectal Carcinoma	GDSC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.A98T	ACH-000958	Colon/Colorectal Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.A98T	SW48	large intestine	COSMIC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.E90K	ACH-000960	Leukemia	CCLE	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVI2B

UniProt ID: P34910

Entrez ID: 2124

Protein name: Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVI2B in