DegronMD - P34910(EVI2B)

FUNCTION: Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}.

GO - Biological processes (BP): myeloid cell development [GO:0061515]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of neutrophil differentiation [GO:0045660]; regulation of cell cycle [GO:0051726]; regulation of stem cell division [GO:2... View more >>

GO - Molecular function (MF):

GO - Cellular component (CC): integral component of plasma membrane [GO:0005887]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L117P	DO51414	PRAD	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7582
p.S134C	TCGA-BB-4227	HNSC	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7541
p.S88C	TCGA-DK-A6B6	BLCA	TCGA	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7541
p.G330A	DO12202	GBM	ICGC	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.754
p.T135I	TCGA-85-8276	LUSC	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7078
p.Q134K	DO51189	LUAD	ICGC	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6944
p.R132S	TCGA-69-7980	LUAD	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6316
p.K140N	TCGA-06-6697	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.3056
p.K140Q	TCGA-06-6697	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.3056
p.E90Q	TCGA-SX-A71R	KIRP	TCGA	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.D334N	DO51595	CESC	ICGC	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.Q84K	DO229029	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.S112F	DO23711	LUAD	ICGC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.E90K	ACH-000960	Leukemia	CCLE	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.3056
p.Q119K	TCGA-49-AARQ	LUAD	TCGA	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2778
p.D335Y	TCGA-DF-A2KV	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.G83E	DO38855	STAD	ICGC	VYTSS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2778
p.K107E	SIDM00600	Thyroid Gland Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778
p.K107E	ACH-001528	Thyroid Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778
p.K107E	ACH-002055	Lymphoma	CCLE	ANTSS	DEG_SPOP_SBC_1	113:117	Mutation substituting flanking lysine	0.2778

Showing 1 to 20 of 46 entries

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Kaplan plot for EVI2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVI2B

UniProt ID: P34910

Entrez ID: 2124

Protein name: Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVI2B in