DegronMD

Uniprot ID: P34910

Source protein: Protein EVI2B

Source gene: EVI2B

Class: DEG_SPOP_SBC_1

Location: 85:89

E3 ligase: SPOP

DEGRON score: 0.958

ASA_SCORE: 87.06

COIL: 0.7604

CONS_SCORE: 0.5349

DSS_SCORE: 0.6587

HELIX: 0.0172

FCONS_SCORE: 1.0847

RIG_SCORE: 0.6814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S97F	TCGA-75-5126	LUAD	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1111
p.Q80K	TCGA-D8-A1XL	BRCA	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1944
p.S88C	TCGA-DK-A6B6	BLCA	TCGA	VYTSS	DEG_SPOP_SBC_1	0.7541
p.E90Q	TCGA-SX-A71R	KIRP	TCGA	VYTSS	DEG_SPOP_SBC_1	0.3056
p.Q95K	DO1648	BRCA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1667
p.F77L	DO228986	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1111
p.Q84K	DO229029	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.3056
p.P96T	DO229036	LICA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1389
p.G83E	DO38855	STAD	ICGC	VYTSS	DEG_SPOP_SBC_1	0.2778
p.A98T	SIDM00837	Colorectal Carcinoma	GDSC	VYTSS	DEG_SPOP_SBC_1	0.0833
p.A98T	ACH-000958	Colon/Colorectal Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	0.0833
p.A98T	SW48	large_intestine	COSMIC	VYTSS	DEG_SPOP_SBC_1	0.0833
p.E90K	ACH-000960	Leukemia	CCLE	VYTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00519	Fatty-acid amide hydrolase 1	DEG_SPOP_SBC_1	318:322	VYTSS	SPOP	0.7806	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	85:89	VYTSS	SPOP	0.958	More...
Q9H2F3	3 beta-hydroxysteroid dehydrogenase type 7	DEG_SPOP_SBC_1	125:129	VYTSS	SPOP	0.553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons