DegronMD

Uniprot ID: O00519

Source protein: Fatty-acid amide hydrolase 1

Source gene: FAAH

Class: DEG_SPOP_SBC_1

Location: 318:322

E3 ligase: SPOP

DEGRON score: 0.7806

ASA_SCORE: 69.54

COIL: 0.8346

CONS_SCORE: 0.2447

DSS_SCORE: 0.3106

HELIX: 0.1508

FCONS_SCORE: 0.5344

RIG_SCORE: 0.77

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V318F	TCGA-78-8662	LUAD	TCGA	VYTSS	DEG_SPOP_SBC_1	0.7068
p.V309A	TCGA-A2-A0YC	BRCA	TCGA	VYTSS	DEG_SPOP_SBC_1	0.0833
p.V309A	DO1250	BRCA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.0833
p.F314L	TCGA-A8-A09G	BRCA	TCGA	VYTSS	DEG_SPOP_SBC_1	0.2222
p.F314L	DO1990	BRCA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.2222
p.R326C	TCGA-AP-A0LM	UCEC	TCGA	VYTSS	DEG_SPOP_SBC_1	0.2222
p.R326C	TCGA-XK-AAIW	PRAD	TCGA	VYTSS	DEG_SPOP_SBC_1	0.2222
p.R326C	DO51407	PRAD	ICGC	VYTSS	DEG_SPOP_SBC_1	0.2222
p.R326C	DO43306	UCEC	ICGC	VYTSS	DEG_SPOP_SBC_1	0.2222
p.P311L	TCGA-D3-A8GM	SKCM	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1389
p.P311L	DO50288	SKCM	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1389
p.P313L	TCGA-EB-A3Y7	SKCM	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1944
p.P313L	DO37499	SKCM	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1944
p.P311S	TCGA-K4-A54R	BLCA	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1389
p.P311S	DO48611	BLCA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1389
p.P324T	DO222654	ESCA	ICGC	VYTSS	DEG_SPOP_SBC_1	0.2778
p.L325P	SIDM00557	Neuroblastoma	GDSC	VYTSS	DEG_SPOP_SBC_1	0.25
p.L325P	SIDM01757	Bladder Carcinoma	GDSC	VYTSS	DEG_SPOP_SBC_1	0.25
p.L325P	ACH-000741	Bladder Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	0.25
p.L325R	ACH-001380	Pancreatic Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00519	Fatty-acid amide hydrolase 1	DEG_SPOP_SBC_1	318:322	VYTSS	SPOP	0.7806	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	85:89	VYTSS	SPOP	0.958	More...
Q9H2F3	3 beta-hydroxysteroid dehydrogenase type 7	DEG_SPOP_SBC_1	125:129	VYTSS	SPOP	0.553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons