DegronMD

Uniprot ID: Q9H2F3

Source protein: 3 beta-hydroxysteroid dehydrogenase type 7

Source gene: HSD3B7

Class: DEG_SPOP_SBC_1

Location: 125:129

E3 ligase: SPOP

DEGRON score: 0.553

ASA_SCORE: 7.54

COIL: 0.3794

CONS_SCORE: 0.7302

DSS_SCORE: 0.298

HELIX: 0.0058

FCONS_SCORE: 1.4087

RIG_SCORE: 0.866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T119N	TCGA-BR-A4IY	STAD	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1667
p.T119N	DO38396	STAD	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1667
p.G120E	TCGA-D3-A5GO	SKCM	TCGA	VYTSS	DEG_SPOP_SBC_1	0.1944
p.G120E	DO47419	SKCM	ICGC	VYTSS	DEG_SPOP_SBC_1	0.1944
p.F123L	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VYTSS	DEG_SPOP_SBC_1	0.2778
p.F123L	ACH-000891	Lung Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00519	Fatty-acid amide hydrolase 1	DEG_SPOP_SBC_1	318:322	VYTSS	SPOP	0.7806	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	85:89	VYTSS	SPOP	0.958	More...
Q9H2F3	3 beta-hydroxysteroid dehydrogenase type 7	DEG_SPOP_SBC_1	125:129	VYTSS	SPOP	0.553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons