DegronMD - O00519(FAAH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V318F	TCGA-78-8662	LUAD	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7068
p.V309A	TCGA-A2-A0YC	BRCA	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.V309A	DO1250	BRCA	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.F314L	TCGA-A8-A09G	BRCA	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.F314L	DO1990	BRCA	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.R326C	TCGA-AP-A0LM	UCEC	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.R326C	TCGA-XK-AAIW	PRAD	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.R326C	DO51407	PRAD	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.R326C	DO43306	UCEC	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.P311L	TCGA-D3-A8GM	SKCM	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.P311L	DO50288	SKCM	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.P313L	TCGA-EB-A3Y7	SKCM	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1944
p.P313L	DO37499	SKCM	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1944
p.P311S	TCGA-K4-A54R	BLCA	TCGA	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.P311S	DO48611	BLCA	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.P324T	DO222654	ESCA	ICGC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.L325P	SIDM00557	Neuroblastoma	GDSC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.L325P	SIDM01757	Bladder Carcinoma	GDSC	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.L325P	ACH-000741	Bladder Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.L325R	ACH-001380	Pancreatic Cancer	CCLE	VYTSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25

Kaplan plot for FAAH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAAH

UniProt ID: O00519

Entrez ID: 2166

Protein name: Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAAH in