DegronMD

Uniprot ID: P34910

Source protein: Protein EVI2B

Source gene: EVI2B

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.9564

ASA_SCORE: 99.22

COIL: 0.9178

CONS_SCORE: 0.5923

DSS_SCORE: 0.5996

HELIX: 0.0282

FCONS_SCORE: 1.0269

RIG_SCORE: 0.6383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K140N	TCGA-06-6697	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	0.3056
p.K140Q	TCGA-06-6697	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	0.3056
p.R132S	TCGA-69-7980	LUAD	TCGA	ARTST	DEG_SPOP_SBC_1	0.6316
p.T135I	TCGA-85-8276	LUSC	TCGA	ARTST	DEG_SPOP_SBC_1	0.7078
p.S134C	TCGA-BB-4227	HNSC	TCGA	ARTST	DEG_SPOP_SBC_1	0.7541
p.P124T	DO18084	KIRC	ICGC	ARTST	DEG_SPOP_SBC_1	0.1389
p.Q134K	DO51189	LUAD	ICGC	ARTST	DEG_SPOP_SBC_1	0.6944
p.P126A	DO229540	UTCA	ICGC	ARTST	DEG_SPOP_SBC_1	0.1944
p.V121M	SIDM00487	Colorectal Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	0.0556
p.V121M	ACH-000963	Colon/Colorectal Cancer	CCLE	ARTST	DEG_SPOP_SBC_1	0.0556
p.V121M	CCK-81	large_intestine	COSMIC	ARTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34910	Protein EVI2B	DEG_SPOP_SBC_1	131:135	ARTST	SPOP	0.9564	More...
Q969P0	Immunoglobulin superfamily member 8	DEG_SPOP_SBC_1	188:192	ARTST	SPOP	0.687	More...
P59797	Selenoprotein V	DEG_SPOP_SBC_1	13:17	ARTST	SPOP	0.9397	More...
Q9Y2H8	Zinc finger protein 510	DEG_SPOP_SBC_1	582:586	ARTST	SPOP	0.9685	More...
Q9Y6S9	Ribosomal protein S6 kinase-like 1	DEG_SPOP_SBC_1	308:312	ARTST	SPOP	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons