DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ARTST
Uniprot ID:
P59797
Source protein:
Selenoprotein V
Source gene:
SELENOV
Class:
DEG_SPOP_SBC_1
Location:
13:17
E3 ligase:
SPOP
DEGRON score:
0.9397
ASA_SCORE:
96.88
COIL:
0.9338
CONS_SCORE:
0.3949
DSS_SCORE:
0.8019
HELIX:
0.0214
FCONS_SCORE:
0.5523
RIG_SCORE:
0.5767
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SELENOV mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P34910
Protein EVI2B
DEG_SPOP_SBC_1
131:135
ARTST
SPOP
0.9564
More...
Q969P0
Immunoglobulin superfamily member 8
DEG_SPOP_SBC_1
188:192
ARTST
SPOP
0.687
More...
P59797
Selenoprotein V
DEG_SPOP_SBC_1
13:17
ARTST
SPOP
0.9397
More...
Q9Y2H8
Zinc finger protein 510
DEG_SPOP_SBC_1
582:586
ARTST
SPOP
0.9685
More...
Q9Y6S9
Ribosomal protein S6 kinase-like 1
DEG_SPOP_SBC_1
308:312
ARTST
SPOP
0.9916
More...