DegronMD - Q9Y6S9(RPS6KL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q299K	TCGA-EE-A29L	SKCM	TCGA	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.Q299K	DO37835	SKCM	ICGC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.L318I	DO229022	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.A308D	DO229034	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7793
p.S313T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.3056
p.S313T	ACH-000981	Leukemia	CCLE	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.3056
p.S313T	DND-41	haematopoietic and lymphoid tissue	COSMIC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.3056
p.A302T	SIDM00680	Colorectal Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.A302T	ACH-000957	Colon/Colorectal Cancer	CCLE	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.A302T	LS-180	large intestine	COSMIC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.A308T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARTST	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7139

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons