DegronMD

Uniprot ID: Q9Y6S9

Source protein: Ribosomal protein S6 kinase-like 1

Source gene: RPS6KL1

Class: DEG_SPOP_SBC_1

Location: 308:312

E3 ligase: SPOP

DEGRON score: 0.9916

ASA_SCORE: 80.44

COIL: 0.6668

CONS_SCORE: 0.5703

DSS_SCORE: 0.8427

HELIX: 0.0806

FCONS_SCORE: 1.3233

RIG_SCORE: 0.58

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q299K	TCGA-EE-A29L	SKCM	TCGA	ARTST	DEG_SPOP_SBC_1	0.0833
p.Q299K	DO37835	SKCM	ICGC	ARTST	DEG_SPOP_SBC_1	0.0833
p.L318I	DO229022	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.A308D	DO229034	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	0.7793
p.S313T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARTST	DEG_SPOP_SBC_1	0.3056
p.S313T	ACH-000981	Leukemia	CCLE	ARTST	DEG_SPOP_SBC_1	0.3056
p.S313T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ARTST	DEG_SPOP_SBC_1	0.3056
p.A302T	SIDM00680	Colorectal Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	0.1667
p.A302T	ACH-000957	Colon/Colorectal Cancer	CCLE	ARTST	DEG_SPOP_SBC_1	0.1667
p.A302T	LS-180	large_intestine	COSMIC	ARTST	DEG_SPOP_SBC_1	0.1667
p.A308T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARTST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34910	Protein EVI2B	DEG_SPOP_SBC_1	131:135	ARTST	SPOP	0.9564	More...
Q969P0	Immunoglobulin superfamily member 8	DEG_SPOP_SBC_1	188:192	ARTST	SPOP	0.687	More...
P59797	Selenoprotein V	DEG_SPOP_SBC_1	13:17	ARTST	SPOP	0.9397	More...
Q9Y2H8	Zinc finger protein 510	DEG_SPOP_SBC_1	582:586	ARTST	SPOP	0.9685	More...
Q9Y6S9	Ribosomal protein S6 kinase-like 1	DEG_SPOP_SBC_1	308:312	ARTST	SPOP	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons