DegronMD - Q969P0(IGSF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A188T	TCGA-06-2569	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.7139
p.A188T	DO12202	GBM	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.7139
p.V206G	TCGA-50-5051	LUAD	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.V206G	DO24576	LUAD	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.A183S	TCGA-53-7624	LUAD	TCGA	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.1944
p.A183S	DO25058	LUAD	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.1944
p.R223W	TCGA-67-3771	LUAD	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.R223W	DO25797	LUAD	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.G185S	TCGA-A5-A0G2	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.G185S	DO41235	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.A188V	TCGA-B5-A1MR	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.5825
p.A188V	DO41758	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.5825
p.S205Y	TCGA-DK-A1AC	BLCA	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1389
p.S205Y	DO514	BLCA	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1389
p.E208K	TCGA-E7-A7XN	BLCA	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.E208K	DO51878	BLCA	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.H195Q	TCGA-EE-A3AA	SKCM	TCGA	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.H195Q	DO222632	MELA	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.H195Q	DO37571	SKCM	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.V228L	TCGA-ER-A3EV	SKCM	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1111
p.V228L	DO48597	SKCM	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1111
p.F202L	TCGA-H6-8124	PAAD	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0556
p.F202L	TCGA-H6-8124	PAAD	TCGA	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.0556
p.F202L	DO32751	PAAD	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0556
p.F202L	DO32751	PAAD	ICGC	ARTST	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.0556
p.A209P	SIDM00849	Kidney Carcinoma	GDSC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.A209P	ACH-000429	Kidney Cancer	CCLE	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.A209P	A704	kidney	COSMIC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.R204Q	SIDM01588	Endometrial Carcinoma	GDSC	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1111
p.R204Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	GRSTLQEVV	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1111

Kaplan plot for IGSF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF8

UniProt ID: Q969P0

Entrez ID: 93185

Protein name: Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF8 in