DegronMD

Uniprot ID: Q969P0

Source protein: Immunoglobulin superfamily member 8

Source gene: IGSF8

Class: DEG_APCC_DBOX_1

Location: 212:220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5474

ASA_SCORE: 55.9333

COIL: 0.2949

CONS_SCORE: 0.6975

DSS_SCORE: 0.3303

HELIX: 0.015

FCONS_SCORE: 1.0073

RIG_SCORE: 0.7737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V206G	TCGA-50-5051	LUAD	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	0.1667
p.V206G	DO24576	LUAD	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	0.1667
p.R223W	TCGA-67-3771	LUAD	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	0.25
p.R223W	DO25797	LUAD	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	0.25
p.S205Y	TCGA-DK-A1AC	BLCA	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	0.1389
p.S205Y	DO514	BLCA	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	0.1389
p.E208K	TCGA-E7-A7XN	BLCA	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	0.2222
p.E208K	DO51878	BLCA	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	0.2222
p.V228L	TCGA-ER-A3EV	SKCM	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	0.1111
p.V228L	DO48597	SKCM	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	0.1111
p.F202L	TCGA-H6-8124	PAAD	TCGA	GRSTLQEVV	DEG_APCC_DBOX_1	0.0556
p.F202L	DO32751	PAAD	ICGC	GRSTLQEVV	DEG_APCC_DBOX_1	0.0556
p.A209P	SIDM00849	Kidney Carcinoma	GDSC	GRSTLQEVV	DEG_APCC_DBOX_1	0.25
p.A209P	ACH-000429	Kidney Cancer	CCLE	GRSTLQEVV	DEG_APCC_DBOX_1	0.25
p.A209P	A704	kidney	COSMIC	GRSTLQEVV	DEG_APCC_DBOX_1	0.25
p.R204Q	SIDM01588	Endometrial Carcinoma	GDSC	GRSTLQEVV	DEG_APCC_DBOX_1	0.1111
p.R204Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	GRSTLQEVV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969P0	Immunoglobulin superfamily member 8	DEG_APCC_DBOX_1	212:220	GRSTLQEVV	APC,CDC20,FZR1	0.5474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons