DegronMD

Uniprot ID: Q969P0

Source protein: Immunoglobulin superfamily member 8

Source gene: IGSF8

Class: DEG_SPOP_SBC_1

Location: 188:192

E3 ligase: SPOP

DEGRON score: 0.687

ASA_SCORE: 69.64

COIL: 0.6542

CONS_SCORE: 0.6295

DSS_SCORE: 0.4309

HELIX: 0.009

FCONS_SCORE: 0.7683

RIG_SCORE: 0.7089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A188T	TCGA-06-2569	GBM	TCGA	ARTST	DEG_SPOP_SBC_1	0.7139
p.A188T	DO12202	GBM	ICGC	ARTST	DEG_SPOP_SBC_1	0.7139
p.A183S	TCGA-53-7624	LUAD	TCGA	ARTST	DEG_SPOP_SBC_1	0.1944
p.A183S	DO25058	LUAD	ICGC	ARTST	DEG_SPOP_SBC_1	0.1944
p.G185S	TCGA-A5-A0G2	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.25
p.G185S	DO41235	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.25
p.A188V	TCGA-B5-A1MR	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.5825
p.A188V	DO41758	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.5825
p.H195Q	TCGA-EE-A3AA	SKCM	TCGA	ARTST	DEG_SPOP_SBC_1	0.25
p.H195Q	DO222632	MELA	ICGC	ARTST	DEG_SPOP_SBC_1	0.25
p.H195Q	DO37571	SKCM	ICGC	ARTST	DEG_SPOP_SBC_1	0.25
p.F202L	TCGA-H6-8124	PAAD	TCGA	ARTST	DEG_SPOP_SBC_1	0.0556
p.F202L	DO32751	PAAD	ICGC	ARTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34910	Protein EVI2B	DEG_SPOP_SBC_1	131:135	ARTST	SPOP	0.9564	More...
Q969P0	Immunoglobulin superfamily member 8	DEG_SPOP_SBC_1	188:192	ARTST	SPOP	0.687	More...
P59797	Selenoprotein V	DEG_SPOP_SBC_1	13:17	ARTST	SPOP	0.9397	More...
Q9Y2H8	Zinc finger protein 510	DEG_SPOP_SBC_1	582:586	ARTST	SPOP	0.9685	More...
Q9Y6S9	Ribosomal protein S6 kinase-like 1	DEG_SPOP_SBC_1	308:312	ARTST	SPOP	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons