DegronMD

Uniprot ID: Q9Y2H8

Source protein: Zinc finger protein 510

Source gene: ZNF510

Class: DEG_SPOP_SBC_1

Location: 582:586

E3 ligase: SPOP

DEGRON score: 0.9685

ASA_SCORE: 71.7

COIL: 0.715

CONS_SCORE: 0.538

DSS_SCORE: 0.2883

HELIX: 0.0668

FCONS_SCORE: 0.7318

RIG_SCORE: 0.792

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R592I	TCGA-AA-3984	COAD	TCGA	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	TCGA-AP-A056	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	TCGA-AP-A0LM	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	TCGA-EO-A3B0	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	TCGA-EY-A1GI	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	TCGA-FI-A2D0	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	DO9002	COAD	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	DO219773	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	DO43306	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	DO43891	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	DO41211	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	DO43971	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	SIDM01588	Endometrial Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	0.1667
p.R592I	ACH-000993	Endometrial/Uterine Cancer	CCLE	ARTST	DEG_SPOP_SBC_1	0.1667
p.H590Y	TCGA-BR-6452	STAD	TCGA	ARTST	DEG_SPOP_SBC_1	0.2222
p.H590Y	DO38404	STAD	ICGC	ARTST	DEG_SPOP_SBC_1	0.2222
p.G596V	TCGA-D3-A1Q1	SKCM	TCGA	ARTST	DEG_SPOP_SBC_1	0.0556
p.G596V	DO37445	SKCM	ICGC	ARTST	DEG_SPOP_SBC_1	0.0556
p.R583W	TCGA-EO-A22U	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	0.7523
p.R583W	DO43755	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	0.7523
p.F572L	DO229019	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	0.0556
p.T584K	DO229029	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	0.7306
p.H590N	DO229045	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	0.2222
p.R583Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	0.6218
p.R583Q	SIDM00257	Neuroblastoma	GDSC	ARTST	DEG_SPOP_SBC_1	0.6218
p.R583Q	KYSE-510	oesophagus	COSMIC	ARTST	DEG_SPOP_SBC_1	0.6218
p.R583Q	NB13	autonomic_ganglia	COSMIC	ARTST	DEG_SPOP_SBC_1	0.6218
p.E576K	SIDM00233	T-Lymphoblastic Leukemia	GDSC	ARTST	DEG_SPOP_SBC_1	0.1667
p.E576K	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34910	Protein EVI2B	DEG_SPOP_SBC_1	131:135	ARTST	SPOP	0.9564	More...
Q969P0	Immunoglobulin superfamily member 8	DEG_SPOP_SBC_1	188:192	ARTST	SPOP	0.687	More...
P59797	Selenoprotein V	DEG_SPOP_SBC_1	13:17	ARTST	SPOP	0.9397	More...
Q9Y2H8	Zinc finger protein 510	DEG_SPOP_SBC_1	582:586	ARTST	SPOP	0.9685	More...
Q9Y6S9	Ribosomal protein S6 kinase-like 1	DEG_SPOP_SBC_1	308:312	ARTST	SPOP	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARTST

Degron related mutations and impact score

Drug responses associated with ZNF510 mutations

All proteins holding degron of ARTST