DegronMD - Q9Y2H8(ZNF510)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H116Y	TCGA-94-A5I6	LUSC	TCGA	DYR	CBL_MET	119:121	Mutation rewiring degron network	0.25
p.H116Y	DO219176	LUSC	ICGC	DYR	CBL_MET	119:121	Mutation rewiring degron network	0.25
p.R592I	TCGA-AA-3984	COAD	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	TCGA-AP-A056	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	TCGA-AP-A0LM	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	TCGA-EO-A3B0	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	TCGA-EY-A1GI	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	TCGA-FI-A2D0	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	DO9002	COAD	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	DO219773	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	DO43306	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	DO43891	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	DO41211	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	DO43971	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	SIDM01588	Endometrial Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.R592I	ACH-000993	Endometrial/Uterine Cancer	CCLE	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.K131T	TCGA-AP-A1E0	UCEC	TCGA	DYR	CBL_MET	119:121	Mutation substituting flanking lysine	0.1667
p.K131T	DO43154	UCEC	ICGC	DYR	CBL_MET	119:121	Mutation substituting flanking lysine	0.1667
p.N15D	TCGA-B5-A11E	UCEC	TCGA	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0833
p.N15D	DO41644	UCEC	ICGC	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0833
p.H590Y	TCGA-BR-6452	STAD	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2222
p.H590Y	DO38404	STAD	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2222
p.G596V	TCGA-D3-A1Q1	SKCM	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0556
p.G596V	DO37445	SKCM	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0556
p.R583W	TCGA-EO-A22U	UCEC	TCGA	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.7523
p.R583W	DO43755	UCEC	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.7523
p.T13K	DO228971	LICA	ICGC	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.F572L	DO229019	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0556
p.T584K	DO229029	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.7306
p.H590N	DO229045	LICA	ICGC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2222
p.P5T	DO229045	LICA	ICGC	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.5919
p.S2L	DO222363	MELA	ICGC	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.7667
p.A7V	SIDM00336	Melanoma	GDSC	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.A7V	ACH-000881	Skin Cancer	CCLE	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.A7V	MEL-JUSO	skin	COSMIC	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.R583Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.6218
p.R583Q	SIDM00257	Neuroblastoma	GDSC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.6218
p.R583Q	KYSE-510	oesophagus	COSMIC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.6218
p.R583Q	NB13	autonomic ganglia	COSMIC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.6218
p.E576K	SIDM00233	T-Lymphoblastic Leukemia	GDSC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.E576K	ATN-1	haematopoietic and lymphoid tissue	COSMIC	ARTST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1667
p.T13A	ACH-000999	Colon/Colorectal Cancer	CCLE	MSPHPE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF510

UniProt ID: Q9Y2H8

Entrez ID: 22869

Protein name: Zinc finger protein 510

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF510 in