DegronMD

Uniprot ID: Q9Y2H8

Source protein: Zinc finger protein 510

Source gene: ZNF510

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9109

ASA_SCORE: 102.9

COIL: 0.8773

CONS_SCORE: 0.5537

DSS_SCORE: 0.7694

HELIX: 0.1012

FCONS_SCORE: 1.4676

RIG_SCORE: 0.6731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N15D	TCGA-B5-A11E	UCEC	TCGA	MSPHPE	LIG_APCC_ABBA_1	0.0833
p.N15D	DO41644	UCEC	ICGC	MSPHPE	LIG_APCC_ABBA_1	0.0833
p.T13K	DO228971	LICA	ICGC	MSPHPE	LIG_APCC_ABBA_1	0.1389
p.P5T	DO229045	LICA	ICGC	MSPHPE	LIG_APCC_ABBA_1	0.5919
p.S2L	DO222363	MELA	ICGC	MSPHPE	LIG_APCC_ABBA_1	0.7667
p.A7V	SIDM00336	Melanoma	GDSC	MSPHPE	LIG_APCC_ABBA_1	0.3056
p.A7V	ACH-000881	Skin Cancer	CCLE	MSPHPE	LIG_APCC_ABBA_1	0.3056
p.A7V	MEL-JUSO	skin	COSMIC	MSPHPE	LIG_APCC_ABBA_1	0.3056
p.T13A	ACH-000999	Colon/Colorectal Cancer	CCLE	MSPHPE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H8	Zinc finger protein 510	LIG_APCC_ABBA_1	1:6	MSPHPE	APC,CDC20,FZR1	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons