DegronMD

Uniprot ID: P34910

Source protein: Protein EVI2B

Source gene: EVI2B

Class: DEG_SPOP_SBC_1

Location: 113:117

E3 ligase: SPOP

DEGRON score: 0.7132

ASA_SCORE: 86.42

COIL: 0.9014

CONS_SCORE: 0.568

DSS_SCORE: 0.5841

HELIX: 0.0434

FCONS_SCORE: 1.156

RIG_SCORE: 0.6749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q119K	TCGA-49-AARQ	LUAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2778
p.P109T	TCGA-CJ-4923	KIRC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2222
p.S103C	DO48576	BLCA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0556
p.P124T	DO18084	KIRC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.E105Q	DO49777	KIRP	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.S112F	DO23711	LUAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.3056
p.L117P	DO51414	PRAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7582
p.P126A	DO229540	UTCA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0833
p.K107E	SIDM00600	Thyroid Gland Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.2778
p.K107E	ACH-001528	Thyroid Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.2778
p.K107E	ACH-002055	Lymphoma	CCLE	ANTSS	DEG_SPOP_SBC_1	0.2778
p.K107E	IHH-4	thyroid	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.2778
p.V121M	SIDM00487	Colorectal Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.2222
p.V121M	ACH-000963	Colon/Colorectal Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.2222
p.V121M	CCK-81	large_intestine	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons