DegronMD - Q7L4P6(BEND5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A284T	TCGA-58-8391	LUSC	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.A284T	DO50341	ESAD	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.A284T	DO45440	LUSC	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.T278A	TCGA-5M-AAT6	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.T278A	DO223703	COAD	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.S280F	TCGA-A5-A0VP	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7982
p.S280F	DO42600	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7982
p.S273N	TCGA-AA-3811	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.S273N	DO7962	COAD	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.A286V	TCGA-CG-4460	STAD	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.A286V	DO38427	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.R269Q	TCGA-DD-A4NK	LIHC	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.R269Q	DO44882	LIHC	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.T271I	TCGA-EE-A182	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1944
p.T271I	DO37814	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1944
p.T278M	TCGA-EO-A22U	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7423
p.T278M	DO43755	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7423
p.S279L	TCGA-ND-A4WC	UCS	TCGA	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7667
p.S279L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7667
p.S279L	ACH-000945	Lung Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7667
p.S279L	NCI-H650	lung	COSMIC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7667
p.R269W	DO228944	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.R269W	SIDM02028	Esophageal Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.P287T	DO229035	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.P283L	DO220877	MELA	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.D290Y	DO229275	THCA	ICGC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.E275K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.3056
p.E275K	ACH-000777	Esophageal Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.3056
p.E274Q	ACH-001857	Bile Duct Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BEND5

UniProt ID: Q7L4P6

Entrez ID: 79656

Protein name: BEN domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BEND5 in