DegronMD

Uniprot ID: Q7L4P6

Source protein: BEN domain-containing protein 5

Source gene: BEND5

Class: DEG_SPOP_SBC_1

Location: 276:280

E3 ligase: SPOP

DEGRON score: 0.9905

ASA_SCORE: 74.86

COIL: 0.8252

CONS_SCORE: 0.664

DSS_SCORE: 0.4296

HELIX: 0.141

FCONS_SCORE: 1.0614

RIG_SCORE: 0.6794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A284T	TCGA-58-8391	LUSC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2222
p.A284T	DO50341	ESAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.2222
p.A284T	DO45440	LUSC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.2222
p.T278A	TCGA-5M-AAT6	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.7139
p.T278A	DO223703	COAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7139
p.S280F	TCGA-A5-A0VP	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.7982
p.S280F	DO42600	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7982
p.S273N	TCGA-AA-3811	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.25
p.S273N	DO7962	COAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.25
p.A286V	TCGA-CG-4460	STAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1667
p.A286V	DO38427	STAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1667
p.R269Q	TCGA-DD-A4NK	LIHC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.R269Q	DO44882	LIHC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.T271I	TCGA-EE-A182	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1944
p.T271I	DO37814	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1944
p.T278M	TCGA-EO-A22U	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.7423
p.T278M	DO43755	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.7423
p.S279L	TCGA-ND-A4WC	UCS	TCGA	ANTSS	DEG_SPOP_SBC_1	0.7667
p.S279L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.7667
p.S279L	ACH-000945	Lung Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.7667
p.S279L	NCI-H650	lung	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.7667
p.R269W	DO228944	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.R269W	SIDM02028	Esophageal Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.P287T	DO229035	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.P283L	DO220877	MELA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.25
p.D290Y	DO229275	THCA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0556
p.E275K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.3056
p.E275K	ACH-000777	Esophageal Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.3056
p.E274Q	ACH-001857	Bile Duct Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ANTSS

Degron related mutations and impact score

Drug responses associated with BEND5 mutations

All proteins holding degron of ANTSS