DegronMD

Uniprot ID: Q9Y2F9

Source protein: BTB/POZ domain-containing protein 3

Source gene: BTBD3

Class: DEG_SPOP_SBC_1

Location: 33:37

E3 ligase: SPOP

DEGRON score: 0.7292

ASA_SCORE: 96.8

COIL: 0.9468

CONS_SCORE: 0.4294

DSS_SCORE: 0.6203

HELIX: 0.0364

FCONS_SCORE: 1.0045

RIG_SCORE: 0.5829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K27N	TCGA-AP-A059	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.6111
p.K27N	DO41361	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.6111
p.S38I	SIDM01205	Acute Myeloid Leukemia	GDSC	ANTSS	DEG_SPOP_SBC_1	0.75
p.S38I	ACH-002314	Leukemia	CCLE	ANTSS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons