DegronMD

Uniprot ID: O60281

Source protein: Zinc finger protein 292

Source gene: ZNF292

Class: DEG_SPOP_SBC_1

Location: 2504:2508

E3 ligase: SPOP

DEGRON score: 0.6378

ASA_SCORE: 85.96

COIL: 0.8142

CONS_SCORE: 0.3219

DSS_SCORE: 0.5833

HELIX: 0.1338

FCONS_SCORE: 0.7592

RIG_SCORE: 0.6683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2515H	TCGA-D3-A2JC	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.A2499S	DO229036	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1944
p.S2511G	DO231681	LINC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.25
p.N2494S	DO229293	LMS	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0556
p.Q2510H	DO47578	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	0.2778
p.V2500I	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.2222
p.V2500I	ACH-001498	Lymphoma	CCLE	ANTSS	DEG_SPOP_SBC_1	0.2222
p.V2500I	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.2222
p.N2509K	SIDM01611	Endometrial Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.3056
p.N2509K	ACH-000996	Endometrial/Uterine Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.3056
p.V2495I	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons