DegronMD

Uniprot ID: Q2VWP7

Source protein: Protogenin

Source gene: PRTG

Class: DEG_APCC_DBOX_1

Location: 406:414

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5106

ASA_SCORE: 52.1

COIL: 0.1271

CONS_SCORE: 0.6544

DSS_SCORE: 0.3317

HELIX: 0.0063

FCONS_SCORE: 1.009

RIG_SCORE: 0.7892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A408T	TCGA-55-8094	LUAD	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	0.6028
p.A408T	DO24150	LUAD	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	0.6028
p.A408T	ACH-001395	Breast Cancer	CCLE	SRARLTVVM	DEG_APCC_DBOX_1	0.6028
p.R407K	TCGA-63-A5MS	LUSC	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	0.7237
p.R407K	DO219161	LUSC	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	0.7237
p.A397S	TCGA-AN-A0AJ	BRCA	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	0.0833
p.A397S	DO6040	BRCA	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	0.0833
p.S415P	TCGA-EY-A1GD	UCEC	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	0.3056
p.S415P	DO42129	UCEC	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	0.3056
p.I404V	TCGA-UF-A71D	HNSC	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	0.2778
p.I404V	DO52109	HNSC	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	0.2778
p.A397T	TCGA-W3-A828	SKCM	TCGA	SRARLTVVM	DEG_APCC_DBOX_1	0.0833
p.A397T	DO51273	SKCM	ICGC	SRARLTVVM	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VWP7	Protogenin	DEG_APCC_DBOX_1	406:414	SRARLTVVM	APC,CDC20,FZR1	0.5106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons