DegronMD

Uniprot ID: Q9H694

Source protein: Protein bicaudal C homolog 1

Source gene: BICC1

Class: DEG_SCF_FBW7_1

Location: 751:757

E3 ligase: FBXW7

DEGRON score: 0.98

ASA_SCORE: 63.7143

COIL: 0.7671

CONS_SCORE: 0.5645

DSS_SCORE: 0.3423

HELIX: 0.0497

FCONS_SCORE: 0.9506

RIG_SCORE: 0.7717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L743V	TCGA-2H-A9GR	ESCA	TCGA	VRTPTNT	DEG_SCF_FBW7_1	0.1111
p.E750A	TCGA-CG-5720	STAD	TCGA	VRTPTNT	DEG_SCF_FBW7_1	0.3056
p.T749M	TCGA-D1-A15X	UCEC	TCGA	VRTPTNT	DEG_SCF_FBW7_1	0.2778
p.T749M	TCGA-VS-A9UD	CESC	TCGA	VRTPTNT	DEG_SCF_FBW7_1	0.2778
p.T749K	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VRTPTNT	DEG_SCF_FBW7_1	0.2778
p.T749K	ACH-000408	Esophageal Cancer	CCLE	VRTPTNT	DEG_SCF_FBW7_1	0.2778
p.T749K	TE-5	oesophagus	COSMIC	VRTPTNT	DEG_SCF_FBW7_1	0.2778
p.V751D	SIDM00537	Colorectal Carcinoma	GDSC	VRTPTNT	DEG_SCF_FBW7_1	0.7785
p.V751D	ACH-000982	Colon/Colorectal Cancer	CCLE	VRTPTNT	DEG_SCF_FBW7_1	0.7785
p.V751D	ACH-001345	Colon/Colorectal Cancer	CCLE	VRTPTNT	DEG_SCF_FBW7_1	0.7785
p.V751D	GP5d	large_intestine	COSMIC	VRTPTNT	DEG_SCF_FBW7_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H694	Protein bicaudal C homolog 1	DEG_SCF_FBW7_1	751:757	VRTPTNT	FBXW7	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons