DegronMD

Uniprot ID: Q9H694

Source protein: Protein bicaudal C homolog 1

Source gene: BICC1

Class: DEG_SPOP_SBC_1

Location: 583:587

E3 ligase: SPOP

DEGRON score: 0.8688

ASA_SCORE: 59.16

COIL: 0.6742

CONS_SCORE: 0.3353

DSS_SCORE: 0.4315

HELIX: 0.0652

FCONS_SCORE: 0.966

RIG_SCORE: 0.7072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I584M	TCGA-BA-6871	HNSC	TCGA	AISTS	DEG_SPOP_SBC_1	0.6507
p.S587L	TCGA-CV-A6K2	HNSC	TCGA	AISTS	DEG_SPOP_SBC_1	0.7667
p.H573Q	TCGA-D1-A3JQ	UCEC	TCGA	AISTS	DEG_SPOP_SBC_1	0.0556
p.L589P	TCGA-EE-A3J5	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	0.2778
p.A596V	TCGA-EY-A1GU	UCEC	TCGA	AISTS	DEG_SPOP_SBC_1	0.0833
p.E591K	TCGA-FS-A1ZP	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	0.2222
p.S576P	TCGA-QG-A5Z2	COAD	TCGA	AISTS	DEG_SPOP_SBC_1	0.5833
p.G582R	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	0.3056
p.G582R	ACH-000892	Lung Cancer	CCLE	AISTS	DEG_SPOP_SBC_1	0.3056
p.G582R	NCI-H1563	lung	COSMIC	AISTS	DEG_SPOP_SBC_1	0.3056
p.G590E	ACH-001028	Rhabdoid	CCLE	AISTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	149:153	AISTS	SPOP	0.6634	More...
P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	DEG_SPOP_SBC_1	14:18	AISTS	SPOP	0.8718	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	2047:2051	AISTS	SPOP	0.9931	More...
Q92633	Lysophosphatidic acid receptor 1	DEG_SPOP_SBC_1	3:7	AISTS	SPOP	0.8246	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	240:244	AISTS	SPOP	0.9994	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	583:587	AISTS	SPOP	0.8688	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1521:1525	AISTS	SPOP	0.7322	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	857:861	AISTS	SPOP	0.8563	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	61:65	AISTS	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons