DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AISTS
Uniprot ID:
Q9UK61
Source protein:
Protein TASOR
Source gene:
TASOR
Class:
DEG_SPOP_SBC_1
Location:
857:861
E3 ligase:
SPOP
DEGRON score:
0.8563
ASA_SCORE:
70.04
COIL:
0.8596
CONS_SCORE:
0.4311
DSS_SCORE:
0.2862
HELIX:
0.0786
FCONS_SCORE:
0.9781
RIG_SCORE:
0.7423
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TASOR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AISTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95721
Synaptosomal-associated protein 29
DEG_SPOP_SBC_1
149:153
AISTS
SPOP
0.6634
More...
P13073
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
DEG_SPOP_SBC_1
14:18
AISTS
SPOP
0.8718
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
DEG_SPOP_SBC_1
2047:2051
AISTS
SPOP
0.9931
More...
Q92633
Lysophosphatidic acid receptor 1
DEG_SPOP_SBC_1
3:7
AISTS
SPOP
0.8246
More...
Q96BA8
Cyclic AMP-responsive element-binding protein 3-like protein 1
DEG_SPOP_SBC_1
240:244
AISTS
SPOP
0.9994
More...
Q9H694
Protein bicaudal C homolog 1
DEG_SPOP_SBC_1
583:587
AISTS
SPOP
0.8688
More...
Q9UHV7
Mediator of RNA polymerase II transcription subunit 13
DEG_SPOP_SBC_1
1521:1525
AISTS
SPOP
0.7322
More...
Q9UK61
Protein TASOR
DEG_SPOP_SBC_1
857:861
AISTS
SPOP
0.8563
More...
Q53QW1
Testis-expressed protein 44
DEG_SPOP_SBC_1
61:65
AISTS
SPOP
0.9981
More...