DegronMD - O95721(SNAP29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E148D	TCGA-AX-A1CE	UCEC	TCGA	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.E148D	DO42280	UCEC	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.A158V	TCGA-EP-A2KB	LIHC	TCGA	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1944
p.A158V	DO22932	LIHC	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1944
p.Q156H	TCGA-FS-A1ZP	SKCM	TCGA	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.Q156H	DO37703	SKCM	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S163G	DO228483	BRCA	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	DO229010	COCA	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	DO234285	ESAD	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00338	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00437	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00632	Non-Cancerous	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00264	Ewing's Sarcoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00466	Ovarian Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00530	Esophageal Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00482	Chronic Myelogenous Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00391	Plasma Cell Myeloma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00821	Kidney Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00294	Small Cell Lung Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00498	Colorectal Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00247	Gastric Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00612	Glioma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01653	Non-Cancerous	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00063	Melanoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00018	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00929	Chondrosarcoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00176	Chondrosarcoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00622	Glioblastoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01105	Melanoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00359	Colorectal Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01695	Acute Myeloid Leukemia	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01735	Biliary Tract Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00168	Head and Neck Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01526	Mesothelioma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00167	Head and Neck Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01770	Gastric Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01464	Pancreatic Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM00161	Biliary Tract Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.S163G	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.5
p.E157K	DO233951	GACA	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.S151I	DO229036	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7341
p.I150V	DO23458	LINC	ICGC	AISTS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.5965
p.R51S	SIDM01169	Ovarian Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	57:61	Mutation rewiring degron network	0.1667
p.R51S	ACH-000885	Ovarian Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	57:61	Mutation rewiring degron network	0.1667
p.R51S	TOV-21G	ovary	COSMIC	AASTS	DEG_SPOP_SBC_1	57:61	Mutation rewiring degron network	0.1667

Kaplan plot for SNAP29 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNAP29

UniProt ID: O95721

Entrez ID: 9342

Protein name: Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNAP29 in