DegronMD

Uniprot ID: Q9UHV7

Source protein: Mediator of RNA polymerase II transcription subunit 13

Source gene: MED13

Class: DEG_SCF_FBW7_1

Location: 1949:1955

E3 ligase: FBXW7

DEGRON score: 0.6834

ASA_SCORE: 70.7571

COIL: 0.8194

CONS_SCORE: 0.5061

DSS_SCORE: 0.3684

HELIX: 0.1049

FCONS_SCORE: 1.0177

RIG_SCORE: 0.7423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1944L	TCGA-CV-7435	HNSC	TCGA	LNTPQDT	DEG_SCF_FBW7_1	0.1944
p.M1944L	DO14918	HNSC	ICGC	LNTPQDT	DEG_SCF_FBW7_1	0.1944
p.M1944I	TCGA-DF-A2KN	UCEC	TCGA	LNTPQDT	DEG_SCF_FBW7_1	0.1944
p.M1944I	DO223282	UCEC	ICGC	LNTPQDT	DEG_SCF_FBW7_1	0.1944
p.S1939G	TCGA-UZ-A9PS	KIRP	TCGA	LNTPQDT	DEG_SCF_FBW7_1	0.0556
p.S1939G	DO219709	KIRP	ICGC	LNTPQDT	DEG_SCF_FBW7_1	0.0556
p.T1940M	SIDM01090	Colorectal Carcinoma	GDSC	LNTPQDT	DEG_SCF_FBW7_1	0.0833
p.T1940M	ACH-000943	Colon/Colorectal Cancer	CCLE	LNTPQDT	DEG_SCF_FBW7_1	0.0833
p.T1940M	RKO	large_intestine	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	0.0833
p.C1957G	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	LNTPQDT	DEG_SCF_FBW7_1	0.2778
p.C1957G	ACH-000379	Lung Cancer	CCLE	LNTPQDT	DEG_SCF_FBW7_1	0.2778
p.C1957G	NCI-H1781	lung	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	0.2778
p.N1943Y	SIDM01019	Acute Myeloid Leukemia	GDSC	LNTPQDT	DEG_SCF_FBW7_1	0.1667
p.N1943Y	ACH-002258	Leukemia	CCLE	LNTPQDT	DEG_SCF_FBW7_1	0.1667
p.N1943Y	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	0.1667
p.F1963S	SIDM00118	Colorectal Carcinoma	GDSC	LNTPQDT	DEG_SCF_FBW7_1	0.1111
p.F1963S	ACH-001081	Colon/Colorectal Cancer	CCLE	LNTPQDT	DEG_SCF_FBW7_1	0.1111
p.F1963S	HCC2998	large_intestine	COSMIC	LNTPQDT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SCF_FBW7_1	1949:1955	LNTPQDT	FBXW7	0.6834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons