DegronMD - Q9H7P6(MVB12B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M166L	TCGA-85-8479	LUSC	TCGA	PPQY	ITCH	173:176	Mutation rewiring degron network	0.1389
p.R196I	TCGA-AG-A002	READ	TCGA	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.1389
p.R196I	SIDM01588	Endometrial Carcinoma	GDSC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.1389
p.R196I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.1389
p.R168W	TCGA-BR-4201	STAD	TCGA	PPQY	ITCH	173:176	Mutation rewiring degron network	0.1944
p.S200L	TCGA-CR-6480	HNSC	TCGA	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.25
p.Q202E	TCGA-EK-A2PM	CESC	TCGA	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.3056
p.R164W	TCGA-EO-A3B0	UCEC	TCGA	PPQY	ITCH	173:176	Mutation rewiring degron network	0.0833
p.R164W	TCGA-GN-A269	SKCM	TCGA	PPQY	ITCH	173:176	Mutation rewiring degron network	0.0833
p.Q195E	DO49941	CESC	ICGC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.1111
p.P210S	DO228627	GACA	ICGC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.3056
p.P208S	DO11854	GBM	ICGC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation altering degron motif	0.6752
p.S193L	DO14296	HNSC	ICGC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.0556
p.I180V	DO23038	LIHC	ICGC	PPQY	ITCH	173:176	Mutation rewiring degron network	0.2222
p.P213S	DO220874	MELA	ICGC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation blocking phosphorylation signal	0.6667
p.A209V	DO224633	PACA	ICGC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation altering degron motif	0.6936
p.V194I	SIDM00516	Melanoma	GDSC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.0833
p.V194I	ACH-002166	Skin Cancer	CCLE	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.0833
p.V194I	MZ7-mel	skin	COSMIC	PTTPSQS	DEG_SCF_FBW7_1	203:209	Mutation rewiring degron network	0.0833

Kaplan plot for MVB12B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MVB12B

UniProt ID: Q9H7P6

Entrez ID: 89853

Protein name: Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MVB12B in