DegronMD

Uniprot ID: Q9H7P6

Source protein: Multivesicular body subunit 12B

Source gene: MVB12B

Class: DEG_SCF_FBW7_1

Location: 203:209

E3 ligase: FBXW7

DEGRON score: 0.8831

ASA_SCORE: 80.0429

COIL: 0.9086

CONS_SCORE: 0.5633

DSS_SCORE: 0.8003

HELIX: 0.068

FCONS_SCORE: 1.0735

RIG_SCORE: 0.563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R196I	TCGA-AG-A002	READ	TCGA	PTTPSQS	DEG_SCF_FBW7_1	0.1389
p.R196I	SIDM01588	Endometrial Carcinoma	GDSC	PTTPSQS	DEG_SCF_FBW7_1	0.1389
p.R196I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PTTPSQS	DEG_SCF_FBW7_1	0.1389
p.S200L	TCGA-CR-6480	HNSC	TCGA	PTTPSQS	DEG_SCF_FBW7_1	0.25
p.Q202E	TCGA-EK-A2PM	CESC	TCGA	PTTPSQS	DEG_SCF_FBW7_1	0.3056
p.Q195E	DO49941	CESC	ICGC	PTTPSQS	DEG_SCF_FBW7_1	0.1111
p.P210S	DO228627	GACA	ICGC	PTTPSQS	DEG_SCF_FBW7_1	0.3056
p.P208S	DO11854	GBM	ICGC	PTTPSQS	DEG_SCF_FBW7_1	0.6752
p.S193L	DO14296	HNSC	ICGC	PTTPSQS	DEG_SCF_FBW7_1	0.0556
p.P213S	DO220874	MELA	ICGC	PTTPSQS	DEG_SCF_FBW7_1	0.6667
p.A209V	DO224633	PACA	ICGC	PTTPSQS	DEG_SCF_FBW7_1	0.6936
p.V194I	SIDM00516	Melanoma	GDSC	PTTPSQS	DEG_SCF_FBW7_1	0.0833
p.V194I	ACH-002166	Skin Cancer	CCLE	PTTPSQS	DEG_SCF_FBW7_1	0.0833
p.V194I	MZ7-mel	skin	COSMIC	PTTPSQS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P6	Multivesicular body subunit 12B	DEG_SCF_FBW7_1	203:209	PTTPSQS	FBXW7	0.8831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons