DegronMD - P35680(HNF1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F528S	TCGA-14-0862	GBM	TCGA	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1667
p.F528S	DO12430	GBM	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1667
p.P519L	TCGA-61-1914	OV	TCGA	PPQY	ITCH	519:522	Mutation altering degron motif	0.7582
p.P519L	DO28105	OV	ICGC	PPQY	ITCH	519:522	Mutation altering degron motif	0.7582
p.D195N	TCGA-AD-6899	COAD	TCGA	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.D195N	DO8818	COAD	ICGC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.T194R	TCGA-AD-6899	COAD	TCGA	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.T194R	DO8818	COAD	ICGC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.R527W	TCGA-AX-A2HD	UCEC	TCGA	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1944
p.R527W	DO42608	UCEC	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1944
p.Y522H	TCGA-BG-A221	UCEC	TCGA	PPQY	ITCH	519:522	Mutation altering degron motif	0.7229
p.Y522H	DO42384	UCEC	ICGC	PPQY	ITCH	519:522	Mutation altering degron motif	0.7229
p.G215R	TCGA-BR-A4IY	STAD	TCGA	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.G215R	DO38396	STAD	ICGC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.M193I	TCGA-EB-A41A	SKCM	TCGA	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.M193I	DO37429	SKCM	ICGC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.S197N	TCGA-EO-A22R	UCEC	TCGA	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.S197N	DO42713	UCEC	ICGC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.R526C	DO222798	COCA	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO220862	MELA	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO36556	READ	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO37442	SKCM	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO38123	SKCM	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO38663	STAD	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO223286	UCEC	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO43891	UCEC	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526C	DO42793	UCEC	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.L525F	DO234409	ESAD	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.25
p.R526H	DO21637	LAML	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526H	DO27739	LUSC	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.R526H	ACH-001377	Pancreatic Cancer	CCLE	PPQY	ITCH	519:522	Mutation rewiring degron network	0.2222
p.H523Y	DO36860	READ	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.3056
p.G531E	DO48665	SKCM	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.0833
p.A527V	DO43755	UCEC	ICGC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1944
p.M532V	SIDM01137	Pancreatic Carcinoma	GDSC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.0556
p.H214Q	SIDM00845	Burkitt's Lymphoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.H214Q	SIDM00461	Acute Myeloid Leukemia	GDSC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.H214Q	SIDM01519	Head and Neck Carcinoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.H214Q	ACH-000786	Lymphoma	CCLE	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.S213N	SIDM00845	Burkitt's Lymphoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.S213N	SIDM00461	Acute Myeloid Leukemia	GDSC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.S213N	SIDM01519	Head and Neck Carcinoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.S213N	ACH-000786	Lymphoma	CCLE	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.S213N	ACH-000992	Head and Neck Cancer	CCLE	LFLFPE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.A514T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1944
p.A514T	ACH-000938	Leukemia	CCLE	PPQY	ITCH	519:522	Mutation rewiring degron network	0.1944

Kaplan plot for HNF1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNF1B

UniProt ID: P35680

Entrez ID: 6928

Protein name: Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HNF1B in