DegronMD

Uniprot ID: P35680

Source protein: Hepatocyte nuclear factor 1-beta

Source gene: HNF1B

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7975

ASA_SCORE: 77.05

COIL: 0.5902

CONS_SCORE: 0.353

DSS_SCORE: 0.5862

HELIX: 0.3067

FCONS_SCORE: 1.0126

RIG_SCORE: 0.7964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D195N	TCGA-AD-6899	COAD	TCGA	LFLFPE	LIG_APCC_ABBA_1	0.1111
p.D195N	DO8818	COAD	ICGC	LFLFPE	LIG_APCC_ABBA_1	0.1111
p.T194R	TCGA-AD-6899	COAD	TCGA	LFLFPE	LIG_APCC_ABBA_1	0.0833
p.T194R	DO8818	COAD	ICGC	LFLFPE	LIG_APCC_ABBA_1	0.0833
p.G215R	TCGA-BR-A4IY	STAD	TCGA	LFLFPE	LIG_APCC_ABBA_1	0.1389
p.G215R	DO38396	STAD	ICGC	LFLFPE	LIG_APCC_ABBA_1	0.1389
p.M193I	TCGA-EB-A41A	SKCM	TCGA	LFLFPE	LIG_APCC_ABBA_1	0.0556
p.M193I	DO37429	SKCM	ICGC	LFLFPE	LIG_APCC_ABBA_1	0.0556
p.S197N	TCGA-EO-A22R	UCEC	TCGA	LFLFPE	LIG_APCC_ABBA_1	0.1667
p.S197N	DO42713	UCEC	ICGC	LFLFPE	LIG_APCC_ABBA_1	0.1667
p.H214Q	SIDM00845	Burkitt's Lymphoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	0.1667
p.H214Q	SIDM00461	Acute Myeloid Leukemia	GDSC	LFLFPE	LIG_APCC_ABBA_1	0.1667
p.H214Q	SIDM01519	Head and Neck Carcinoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	0.1667
p.H214Q	ACH-000786	Lymphoma	CCLE	LFLFPE	LIG_APCC_ABBA_1	0.1667
p.S213N	SIDM00845	Burkitt's Lymphoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	0.1944
p.S213N	SIDM00461	Acute Myeloid Leukemia	GDSC	LFLFPE	LIG_APCC_ABBA_1	0.1944
p.S213N	SIDM01519	Head and Neck Carcinoma	GDSC	LFLFPE	LIG_APCC_ABBA_1	0.1944
p.S213N	ACH-000786	Lymphoma	CCLE	LFLFPE	LIG_APCC_ABBA_1	0.1944
p.S213N	ACH-000992	Head and Neck Cancer	CCLE	LFLFPE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35680	Hepatocyte nuclear factor 1-beta	LIG_APCC_ABBA_1	203:208	LFLFPE	APC,CDC20,FZR1	0.7975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons