DegronMD - Q15751(HERC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2636S	TCGA-21-1079	LUSC	TCGA	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation altering degron motif	0.6005
p.T2636S	DO26846	LUSC	ICGC	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation altering degron motif	0.6005
p.P3957H	TCGA-2W-A8YY	CESC	TCGA	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2778
p.P3957H	DO223732	CESC	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2778
p.D4380H	TCGA-2Z-A9JQ	KIRP	TCGA	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.25
p.D4380H	DO219684	KIRP	ICGC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.25
p.T1175M	TCGA-60-2704	LUSC	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.7423
p.T1175M	TCGA-60-2704	LUSC	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation altering degron motif	0.6312
p.T1175M	DO26555	LUSC	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.7423
p.T1175M	DO26555	LUSC	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation altering degron motif	0.6312
p.Q1188R	TCGA-A6-3809	COAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.Q1188R	TCGA-A6-3809	COAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1111
p.Q1188R	DO8722	COAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.Q1188R	DO8722	COAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1111
p.T1169I	TCGA-A6-5665	COAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2222
p.T1169I	TCGA-A6-5665	COAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1944
p.T1169I	DO9756	COAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2222
p.T1169I	DO9756	COAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1944
p.A4388V	TCGA-AA-3947	COAD	TCGA	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.2778
p.A4388V	DO8192	COAD	ICGC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.2778
p.S3949Y	TCGA-AN-A046	BRCA	TCGA	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation altering degron motif	0.712
p.S3949Y	DO1285	BRCA	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation altering degron motif	0.712
p.N3942D	TCGA-AP-A0LI	UCEC	TCGA	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.1667
p.N3942D	DO50749	LICA	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.1667
p.N3942D	DO43658	UCEC	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.1667
p.R2297M	TCGA-B0-5096	KIRC	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.1944
p.R2297M	DO19218	KIRC	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.1944
p.R2297M	ACH-000954	Endometrial/Uterine Cancer	CCLE	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.1944
p.R2297S	TCGA-B5-A11R	UCEC	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.1944
p.R2297S	DO43787	UCEC	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.1944
p.E1166V	TCGA-BH-A0AZ	BRCA	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1389
p.E1166V	TCGA-BH-A0AZ	BRCA	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1111
p.E1166V	DO4725	BRCA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1389
p.E1166V	DO4725	BRCA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1111
p.D2290Y	TCGA-CC-A7IK	LIHC	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.6214
p.D2290Y	DO52184	LIHC	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.6214
p.G1181S	TCGA-D1-A0ZO	UCEC	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2778
p.G1181S	TCGA-D1-A0ZO	UCEC	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.3056
p.G1181S	TCGA-VQ-A8P2	STAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2778
p.G1181S	TCGA-VQ-A8P2	STAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.3056
p.G1181S	DO51761	STAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2778
p.G1181S	DO51761	STAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.3056
p.G1181S	DO41927	UCEC	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2778
p.G1181S	DO41927	UCEC	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.3056
p.T2643M	TCGA-D1-A15X	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation altering degron motif	0.7423
p.T2643M	DO43274	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation altering degron motif	0.7423
p.F1178L	TCGA-EB-A5SG	SKCM	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.587
p.F1178L	TCGA-EB-A5SG	SKCM	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation altering degron motif	0.6981
p.F1178L	DO48726	SKCM	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.587
p.F1178L	DO48726	SKCM	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation altering degron motif	0.6981
p.P4379L	TCGA-EE-A3JD	SKCM	TCGA	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.2222
p.P4379L	DO50299	SKCM	ICGC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.2222
p.D2625G	TCGA-F4-6570	COAD	TCGA	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation rewiring degron network	0.1111
p.D2625G	DO10443	COAD	ICGC	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation rewiring degron network	0.1111
p.D2290N	TCGA-F5-6814	READ	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.5821
p.D2290N	DO36556	READ	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.5821
p.D1185A	TCGA-IB-7651	PAAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.D1185A	TCGA-IB-7651	PAAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1944
p.D1185A	DO46657	PAAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.D1185A	DO46657	PAAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1944
p.P1164L	TCGA-MP-A4TF	LUAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.P1164L	TCGA-MP-A4TF	LUAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.0556
p.P1164L	DO45316	LUAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.P1164L	DO45316	LUAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.0556
p.E2274K	TCGA-OD-A75X	SKCM	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.0556
p.E2274K	DO48601	SKCM	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.0556
p.P4383S	DO233205	GACA	ICGC	PPQY	ITCH	4383:4386	Mutation altering degron motif	0.6752
p.A2289S	DO228288	LICA	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.6477
p.D1185E	DO228952	LICA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.D1185E	DO228952	LICA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1944
p.S2648R	DO228986	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation rewiring degron network	0.2222
p.T2643K	DO228986	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation altering degron motif	0.7306
p.L3955I	DO229029	LICA	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation altering degron motif	0.6063
p.S2637R	DO229022	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation altering degron motif	0.7427
p.Q1167K	DO229035	LICA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.Q1167K	DO229035	LICA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1389
p.A3939D	DO229045	LICA	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.0833
p.P3957T	DO229006	LICA	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2778
p.P2626T	DO229008	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation rewiring degron network	0.1389
p.A3939G	DO23114	LINC	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.0833
p.E3956D	DO23486	LINC	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.3056
p.H4395Y	DO222420	MELA	ICGC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.0833
p.H4395Y	DO222653	MELA	ICGC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.0833
p.P4383L	DO222653	MELA	ICGC	PPQY	ITCH	4383:4386	Mutation altering degron motif	0.7582
p.P3947S	DO222837	MELA	ICGC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.3056
p.A1170S	DO229213	THCA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.A1170S	DO229213	THCA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.2222
p.T2654I	SIDM02049	Pancreatic Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation rewiring degron network	0.0556
p.T2284S	SIDM02034	Colorectal Carcinoma	GDSC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.6005
p.I4394V	SIDM00672	Hepatocellular Carcinoma	GDSC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.1111
p.I4394V	SIDM01112	Osteosarcoma	GDSC	PPQY	ITCH	4383:4386	Mutation rewiring degron network	0.1111
p.P3959S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.S2275N	SIDM00845	Burkitt's Lymphoma	GDSC	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.0833
p.A3944S	SIDM00411	Pancreatic Carcinoma	GDSC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.A3944S	SIDM00600	Thyroid Gland Carcinoma	GDSC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.A3944S	ACH-000332	Pancreatic Cancer	CCLE	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.A3944S	ACH-001528	Thyroid Cancer	CCLE	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.A3944S	ACH-001609	Brain Cancer	CCLE	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.A3944S	IHH-4	thyroid	COSMIC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.A3944S	YAPC	pancreas	COSMIC	ESFTVPDL	DEG_COP1_1	3948:3955	Mutation rewiring degron network	0.2222
p.Q1167E	SIDM00584	Osteosarcoma	GDSC	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.Q1167E	SIDM00584	Osteosarcoma	GDSC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1389
p.Q1167E	ACH-002042	Thyroid Cancer	CCLE	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.Q1167E	ACH-002042	Thyroid Cancer	CCLE	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1389
p.Q1167E	ACH-002142	Bone Cancer	CCLE	MKTPLFS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1667
p.Q1167E	ACH-002142	Bone Cancer	CCLE	KTPLFSD	LIG_APCC_ABBAyCdc20_2	1174:1180	Mutation rewiring degron network	0.1389
p.Q2631R	SIDM00850	Gastric Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation rewiring degron network	0.2778
p.Q2631R	SIDM00850	Gastric Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation rewiring degron network	0.0833
p.Q2631R	ACH-000880	Gastric Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation rewiring degron network	0.2778
p.Q2631R	ACH-000880	Gastric Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation rewiring degron network	0.0833
p.Q2631R	AGS	stomach	COSMIC	PVTTS	DEG_SPOP_SBC_1	2633:2637	Mutation rewiring degron network	0.2778
p.Q2631R	AGS	stomach	COSMIC	ASSTT	DEG_SPOP_SBC_1	2640:2644	Mutation rewiring degron network	0.0833
p.Y4386C	ACH-001518	Endometrial/Uterine Cancer	CCLE	PPQY	ITCH	4383:4386	Mutation altering degron motif	0.7087
p.A2289T	ACH-001536	Bile Duct Cancer	CCLE	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation altering degron motif	0.6028
p.E2293Q	ACH-001694	Head and Neck Cancer	CCLE	TRHGLADLS	DEG_APCC_DBOX_1	2284:2292	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HERC1

UniProt ID: Q15751

Entrez ID: 8925

Protein name: Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HERC1 in