DegronMD

Uniprot ID: Q15751

Source protein: Probable E3 ubiquitin-protein ligase HERC1

Source gene: HERC1

Class: DEG_SCF_FBW7_1

Location: 1173:1179

E3 ligase: FBXW7

DEGRON score: 0.7481

ASA_SCORE: 53.5857

COIL: 0.6184

CONS_SCORE: 0.5038

DSS_SCORE: 0.3934

HELIX: 0.3089

FCONS_SCORE: 1.0951

RIG_SCORE: 0.8229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1175M	TCGA-60-2704	LUSC	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.7423
p.T1175M	DO26555	LUSC	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.7423
p.Q1188R	TCGA-A6-3809	COAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.0833
p.Q1188R	DO8722	COAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.0833
p.T1169I	TCGA-A6-5665	COAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.2222
p.T1169I	DO9756	COAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.2222
p.E1166V	TCGA-BH-A0AZ	BRCA	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.1389
p.E1166V	DO4725	BRCA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.1389
p.G1181S	TCGA-D1-A0ZO	UCEC	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.2778
p.G1181S	TCGA-VQ-A8P2	STAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.2778
p.G1181S	DO51761	STAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.2778
p.G1181S	DO41927	UCEC	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.2778
p.F1178L	TCGA-EB-A5SG	SKCM	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.587
p.F1178L	DO48726	SKCM	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.587
p.D1185A	TCGA-IB-7651	PAAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.1667
p.D1185A	DO46657	PAAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.1667
p.P1164L	TCGA-MP-A4TF	LUAD	TCGA	MKTPLFS	DEG_SCF_FBW7_1	0.0833
p.P1164L	DO45316	LUAD	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.0833
p.D1185E	DO228952	LICA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.1667
p.Q1167K	DO229035	LICA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.1667
p.A1170S	DO229213	THCA	ICGC	MKTPLFS	DEG_SCF_FBW7_1	0.25
p.Q1167E	SIDM00584	Osteosarcoma	GDSC	MKTPLFS	DEG_SCF_FBW7_1	0.1667
p.Q1167E	ACH-002042	Thyroid Cancer	CCLE	MKTPLFS	DEG_SCF_FBW7_1	0.1667
p.Q1167E	ACH-002142	Bone Cancer	CCLE	MKTPLFS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SCF_FBW7_1	1173:1179	MKTPLFS	FBXW7	0.7481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons