DegronMD

Uniprot ID: Q15751

Source protein: Probable E3 ubiquitin-protein ligase HERC1

Source gene: HERC1

Class: DEG_COP1_1

Location: 3948:3955

E3 ligase: COP1

DEGRON score: 0.5016

ASA_SCORE: 66

COIL: 0.6056

CONS_SCORE: 0.6522

DSS_SCORE: 0.4599

HELIX: 0.2194

FCONS_SCORE: 1.09

RIG_SCORE: 0.7808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3957H	TCGA-2W-A8YY	CESC	TCGA	ESFTVPDL	DEG_COP1_1	0.2778
p.P3957H	DO223732	CESC	ICGC	ESFTVPDL	DEG_COP1_1	0.2778
p.S3949Y	TCGA-AN-A046	BRCA	TCGA	ESFTVPDL	DEG_COP1_1	0.712
p.S3949Y	DO1285	BRCA	ICGC	ESFTVPDL	DEG_COP1_1	0.712
p.N3942D	TCGA-AP-A0LI	UCEC	TCGA	ESFTVPDL	DEG_COP1_1	0.1667
p.N3942D	DO50749	LICA	ICGC	ESFTVPDL	DEG_COP1_1	0.1667
p.N3942D	DO43658	UCEC	ICGC	ESFTVPDL	DEG_COP1_1	0.1667
p.L3955I	DO229029	LICA	ICGC	ESFTVPDL	DEG_COP1_1	0.6063
p.A3939D	DO229045	LICA	ICGC	ESFTVPDL	DEG_COP1_1	0.0833
p.P3957T	DO229006	LICA	ICGC	ESFTVPDL	DEG_COP1_1	0.2778
p.A3939G	DO23114	LINC	ICGC	ESFTVPDL	DEG_COP1_1	0.0833
p.E3956D	DO23486	LINC	ICGC	ESFTVPDL	DEG_COP1_1	0.3056
p.P3947S	DO222837	MELA	ICGC	ESFTVPDL	DEG_COP1_1	0.3056
p.P3959S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	SIDM00411	Pancreatic Carcinoma	GDSC	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	SIDM00600	Thyroid Gland Carcinoma	GDSC	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	ACH-000332	Pancreatic Cancer	CCLE	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	ACH-001528	Thyroid Cancer	CCLE	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	ACH-001609	Brain Cancer	CCLE	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	IHH-4	thyroid	COSMIC	ESFTVPDL	DEG_COP1_1	0.2222
p.A3944S	YAPC	pancreas	COSMIC	ESFTVPDL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_COP1_1	3948:3955	ESFTVPDL	COP1	0.5016	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons