DegronMD

Uniprot ID: Q15751

Source protein: Probable E3 ubiquitin-protein ligase HERC1

Source gene: HERC1

Class: DEG_APCC_DBOX_1

Location: 2284:2292

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9834

ASA_SCORE: 76.3

COIL: 0.6811

CONS_SCORE: 0.5926

DSS_SCORE: 0.3622

HELIX: 0.2448

FCONS_SCORE: 1.0722

RIG_SCORE: 0.7584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2297M	TCGA-B0-5096	KIRC	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	0.1944
p.R2297M	DO19218	KIRC	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	0.1944
p.R2297M	ACH-000954	Endometrial/Uterine Cancer	CCLE	TRHGLADLS	DEG_APCC_DBOX_1	0.1944
p.R2297S	TCGA-B5-A11R	UCEC	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	0.1944
p.R2297S	DO43787	UCEC	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	0.1944
p.D2290Y	TCGA-CC-A7IK	LIHC	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	0.6214
p.D2290Y	DO52184	LIHC	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	0.6214
p.D2290N	TCGA-F5-6814	READ	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	0.5821
p.D2290N	DO36556	READ	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	0.5821
p.E2274K	TCGA-OD-A75X	SKCM	TCGA	TRHGLADLS	DEG_APCC_DBOX_1	0.0556
p.E2274K	DO48601	SKCM	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	0.0556
p.A2289S	DO228288	LICA	ICGC	TRHGLADLS	DEG_APCC_DBOX_1	0.6477
p.T2284S	SIDM02034	Colorectal Carcinoma	GDSC	TRHGLADLS	DEG_APCC_DBOX_1	0.6005
p.S2275N	SIDM00845	Burkitt's Lymphoma	GDSC	TRHGLADLS	DEG_APCC_DBOX_1	0.0833
p.A2289T	ACH-001536	Bile Duct Cancer	CCLE	TRHGLADLS	DEG_APCC_DBOX_1	0.6028
p.E2293Q	ACH-001694	Head and Neck Cancer	CCLE	TRHGLADLS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_APCC_DBOX_1	2284:2292	TRHGLADLS	APC,CDC20,FZR1	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons