DegronMD

Uniprot ID: Q15751

Source protein: Probable E3 ubiquitin-protein ligase HERC1

Source gene: HERC1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1174:1180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9697

ASA_SCORE: 57.1429

COIL: 0.694

CONS_SCORE: 0.5091

DSS_SCORE: 0.3777

HELIX: 0.2201

FCONS_SCORE: 1.1062

RIG_SCORE: 0.8108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1175M	TCGA-60-2704	LUSC	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.6312
p.T1175M	DO26555	LUSC	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.6312
p.Q1188R	TCGA-A6-3809	COAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q1188R	DO8722	COAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T1169I	TCGA-A6-5665	COAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.T1169I	DO9756	COAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1166V	TCGA-BH-A0AZ	BRCA	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1166V	DO4725	BRCA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1181S	TCGA-D1-A0ZO	UCEC	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G1181S	TCGA-VQ-A8P2	STAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G1181S	DO51761	STAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G1181S	DO41927	UCEC	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.F1178L	TCGA-EB-A5SG	SKCM	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.F1178L	DO48726	SKCM	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.D1185A	TCGA-IB-7651	PAAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D1185A	DO46657	PAAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1164L	TCGA-MP-A4TF	LUAD	TCGA	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1164L	DO45316	LUAD	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D1185E	DO228952	LICA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q1167K	DO229035	LICA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A1170S	DO229213	THCA	ICGC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q1167E	SIDM00584	Osteosarcoma	GDSC	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q1167E	ACH-002042	Thyroid Cancer	CCLE	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q1167E	ACH-002142	Bone Cancer	CCLE	KTPLFSD	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15751	Probable E3 ubiquitin-protein ligase HERC1	LIG_APCC_ABBAyCdc20_2	1174:1180	KTPLFSD	APC,CDC20,FZR1	0.9697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KTPLFSD

Degron related mutations and impact score

Drug responses associated with HERC1 mutations

All proteins holding degron of KTPLFSD