DegronMD - Q5JTH9(RRP12)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1221C	TCGA-24-1845	OV	TCGA	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.0833
p.R1221C	DO29920	OV	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.0833
p.K57Q	TCGA-2W-A8YY	CESC	TCGA	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.5833
p.K57Q	DO223732	CESC	ICGC	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.5833
p.R836H	TCGA-AX-A1C9	UCEC	TCGA	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.7133
p.R836H	DO43098	UCEC	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.7133
p.E73K	TCGA-BT-A3PJ	BLCA	TCGA	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.2778
p.E73K	TCGA-C8-A8HP	BRCA	TCGA	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.2778
p.E73K	TCGA-DR-A0ZM	CESC	TCGA	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.2778
p.E73K	DO44097	BLCA	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.2778
p.E73K	DO219621	BRCA	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.2778
p.E73K	DO6254	CESC	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.2778
p.E1204K	TCGA-CR-6472	HNSC	TCGA	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1944
p.E1204K	TCGA-QK-A64Z	HNSC	TCGA	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1944
p.E1204K	DO15870	HNSC	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1944
p.E1204K	DO49053	HNSC	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1944
p.S66F	TCGA-DK-AA75	BLCA	TCGA	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation blocking phosphorylation signal	0.5278
p.S66F	TCGA-DK-AA75	BLCA	TCGA	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation blocking phosphorylation signal	0.6389
p.S66F	DO219012	BLCA	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation blocking phosphorylation signal	0.5278
p.S66F	DO219012	BLCA	ICGC	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation blocking phosphorylation signal	0.6389
p.E1204D	TCGA-EE-A181	SKCM	TCGA	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1944
p.E1204D	DO37444	SKCM	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1944
p.G65W	TCGA-EE-A29L	SKCM	TCGA	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.0556
p.G65W	TCGA-EE-A29L	SKCM	TCGA	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.2222
p.G65W	DO37835	SKCM	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.0556
p.G65W	DO37835	SKCM	ICGC	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.2222
p.R1221H	TCGA-EO-A22R	UCEC	TCGA	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.0833
p.R1221H	DO42713	UCEC	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.0833
p.D823N	TCGA-EO-A22U	UCEC	TCGA	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0556
p.D823N	DO43755	UCEC	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0556
p.S848L	TCGA-FD-A6TC	BLCA	TCGA	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1389
p.S848L	DO49755	BLCA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1389
p.P1209S	TCGA-Y8-A894	KIRP	TCGA	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.6752
p.P1209S	DO49798	KIRP	ICGC	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.6752
p.P1222L	DO50437	ESAD	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.0556
p.R826Q	DO233869	GACA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1389
p.S1217F	DO228947	LICA	ICGC	PPQY	ITCH	1209:1212	Mutation blocking phosphorylation signal	0.6389
p.A74D	DO229031	LICA	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.3056
p.R68S	DO229045	LICA	ICGC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation rewiring degron network	0.1389
p.R68S	DO229045	LICA	ICGC	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1389
p.L825M	DO229054	LICA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1111
p.A55D	DO229009	LICA	ICGC	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.3056
p.P56S	DO48726	SKCM	ICGC	VKLHNE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.6752
p.P831L	DO229275	THCA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.2778
p.I1219V	DO234007	THCA	ICGC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1389
p.Q1211H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.647
p.Q1211H	ACH-000995	Leukemia	CCLE	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.647
p.P1210T	SIDM00657	Acute Myeloid Leukemia	GDSC	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.7031
p.P1210T	ACH-000045	Leukemia	CCLE	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.7031
p.P1210T	MV-4-11	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.7031
p.P835S	SIDM01039	Other Solid Cancers	GDSC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.5641
p.P835S	JAR	placenta	COSMIC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.5641
p.P1210S	SIDM00612	Glioma	GDSC	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.6752
p.P1210S	ACH-002257	Brain Cancer	CCLE	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.6752
p.P1210S	KINGS-1	central nervous system	COSMIC	PPQY	ITCH	1209:1212	Mutation altering degron motif	0.6752
p.E76D	SIDM01582	Gastric Carcinoma	GDSC	PETPMEE	DEG_SCF_FBW7_2	75:81	Mutation altering degron motif	0.5647
p.R826W	SIDM01393	Gastric Carcinoma	GDSC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1389
p.R826W	ACH-000466	Gastric Cancer	CCLE	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1389
p.L840P	SIDM01664	Prostate Carcinoma	GDSC	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.7582
p.L840P	ACH-000952	Prostate Cancer	CCLE	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.7582
p.P831S	ACH-001119	Lymphoma	CCLE	KRPRLKCLL	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.2778
p.R1202H	SNG-M	endometrium	COSMIC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1389
p.R1202C	SNU-1040	large intestine	COSMIC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.1389
p.G1214V	COR-L32	lung	COSMIC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.2778
p.K1205N	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	1209:1212	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RRP12

UniProt ID: Q5JTH9

Entrez ID: 23223

Protein name: RRP12-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RRP12 in