DegronMD

Uniprot ID: Q5JTH9

Source protein: RRP12-like protein

Source gene: RRP12

Class: DEG_SCF_FBW7_2

Location: 75:81

E3 ligase: FBXW7

DEGRON score: 0.5604

ASA_SCORE: 106.9

COIL: 0.7784

CONS_SCORE: 0.155

DSS_SCORE: 0.6144

HELIX: 0.193

FCONS_SCORE: 0.9973

RIG_SCORE: 0.6891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E73K	TCGA-BT-A3PJ	BLCA	TCGA	PETPMEE	DEG_SCF_FBW7_2	0.2778
p.E73K	TCGA-C8-A8HP	BRCA	TCGA	PETPMEE	DEG_SCF_FBW7_2	0.2778
p.E73K	TCGA-DR-A0ZM	CESC	TCGA	PETPMEE	DEG_SCF_FBW7_2	0.2778
p.E73K	DO44097	BLCA	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.2778
p.E73K	DO219621	BRCA	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.2778
p.E73K	DO6254	CESC	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.2778
p.S66F	TCGA-DK-AA75	BLCA	TCGA	PETPMEE	DEG_SCF_FBW7_2	0.5278
p.S66F	DO219012	BLCA	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.5278
p.G65W	TCGA-EE-A29L	SKCM	TCGA	PETPMEE	DEG_SCF_FBW7_2	0.0556
p.G65W	DO37835	SKCM	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.0556
p.A74D	DO229031	LICA	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.3056
p.R68S	DO229045	LICA	ICGC	PETPMEE	DEG_SCF_FBW7_2	0.1389
p.E76D	SIDM01582	Gastric Carcinoma	GDSC	PETPMEE	DEG_SCF_FBW7_2	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTH9	RRP12-like protein	DEG_SCF_FBW7_2	75:81	PETPMEE	FBXW7	0.5604	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons