DegronMD

Uniprot ID: Q5JTH9

Source protein: RRP12-like protein

Source gene: RRP12

Class: DEG_APCC_DBOX_1

Location: 833:841

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7892

ASA_SCORE: 44.3333

COIL: 0.0381

CONS_SCORE: 0.5246

DSS_SCORE: 0.2306

HELIX: 0.9609

FCONS_SCORE: 1.3135

RIG_SCORE: 0.8003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R836H	TCGA-AX-A1C9	UCEC	TCGA	KRPRLKCLL	DEG_APCC_DBOX_1	0.7133
p.R836H	DO43098	UCEC	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	0.7133
p.D823N	TCGA-EO-A22U	UCEC	TCGA	KRPRLKCLL	DEG_APCC_DBOX_1	0.0556
p.D823N	DO43755	UCEC	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	0.0556
p.S848L	TCGA-FD-A6TC	BLCA	TCGA	KRPRLKCLL	DEG_APCC_DBOX_1	0.1389
p.S848L	DO49755	BLCA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	0.1389
p.R826Q	DO233869	GACA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	0.1389
p.L825M	DO229054	LICA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	0.1111
p.P831L	DO229275	THCA	ICGC	KRPRLKCLL	DEG_APCC_DBOX_1	0.2778
p.P835S	SIDM01039	Other Solid Cancers	GDSC	KRPRLKCLL	DEG_APCC_DBOX_1	0.5641
p.P835S	JAR	placenta	COSMIC	KRPRLKCLL	DEG_APCC_DBOX_1	0.5641
p.R826W	SIDM01393	Gastric Carcinoma	GDSC	KRPRLKCLL	DEG_APCC_DBOX_1	0.1389
p.R826W	ACH-000466	Gastric Cancer	CCLE	KRPRLKCLL	DEG_APCC_DBOX_1	0.1389
p.L840P	SIDM01664	Prostate Carcinoma	GDSC	KRPRLKCLL	DEG_APCC_DBOX_1	0.7582
p.L840P	ACH-000952	Prostate Cancer	CCLE	KRPRLKCLL	DEG_APCC_DBOX_1	0.7582
p.P831S	ACH-001119	Lymphoma	CCLE	KRPRLKCLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTH9	RRP12-like protein	DEG_APCC_DBOX_1	833:841	KRPRLKCLL	APC,CDC20,FZR1	0.7892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons