DegronMD

Uniprot ID: Q5JTH9

Source protein: RRP12-like protein

Source gene: RRP12

Class: LIG_APCC_ABBA_1

Location: 56:61

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9682

ASA_SCORE: 62.5333

COIL: 0.0303

CONS_SCORE: 0.2756

DSS_SCORE: 0.4271

HELIX: 0.9702

FCONS_SCORE: 1.2577

RIG_SCORE: 0.746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K57Q	TCGA-2W-A8YY	CESC	TCGA	VKLHNE	LIG_APCC_ABBA_1	0.5833
p.K57Q	DO223732	CESC	ICGC	VKLHNE	LIG_APCC_ABBA_1	0.5833
p.S66F	TCGA-DK-AA75	BLCA	TCGA	VKLHNE	LIG_APCC_ABBA_1	0.6389
p.S66F	DO219012	BLCA	ICGC	VKLHNE	LIG_APCC_ABBA_1	0.6389
p.G65W	TCGA-EE-A29L	SKCM	TCGA	VKLHNE	LIG_APCC_ABBA_1	0.2222
p.G65W	DO37835	SKCM	ICGC	VKLHNE	LIG_APCC_ABBA_1	0.2222
p.R68S	DO229045	LICA	ICGC	VKLHNE	LIG_APCC_ABBA_1	0.1389
p.A55D	DO229009	LICA	ICGC	VKLHNE	LIG_APCC_ABBA_1	0.3056
p.P56S	DO48726	SKCM	ICGC	VKLHNE	LIG_APCC_ABBA_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTH9	RRP12-like protein	LIG_APCC_ABBA_1	56:61	VKLHNE	APC,CDC20,FZR1	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons