DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: DEG_APCC_DBOX_1

Location: 524:532

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6385

ASA_SCORE: 93.3111

COIL: 0.9171

CONS_SCORE: 0.2985

DSS_SCORE: 0.7614

HELIX: 0.0442

FCONS_SCORE: 0.9415

RIG_SCORE: 0.6417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R525I	TCGA-EY-A1GI	UCEC	TCGA	KRPQLYGMG	DEG_APCC_DBOX_1	0.8102
p.R525I	DO41211	UCEC	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	0.8102
p.V522L	TCGA-L9-A444	LUAD	TCGA	KRPQLYGMG	DEG_APCC_DBOX_1	0.2778
p.V522L	DO26015	LUAD	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	0.2778
p.Q541H	TCGA-VS-A9V1	CESC	TCGA	KRPQLYGMG	DEG_APCC_DBOX_1	0.0833
p.Q541H	DO51648	CESC	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	0.0833
p.G532D	DO222817	BTCA	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	0.6087
p.G530D	DO233210	GACA	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	0.6087
p.G532C	DO228922	LICA	ICGC	KRPQLYGMG	DEG_APCC_DBOX_1	0.6489
p.G515A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRPQLYGMG	DEG_APCC_DBOX_1	0.0833
p.G515A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	KRPQLYGMG	DEG_APCC_DBOX_1	0.0833
p.M516V	42-MG-BA	central_nervous_system	COSMIC	KRPQLYGMG	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_APCC_DBOX_1	524:532	KRPQLYGMG	APC,CDC20,FZR1	0.6385	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons